Protein Info for PS417_09800 in Pseudomonas simiae WCS417

Annotation: cytosine deaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 411 PF07969: Amidohydro_3" amino acids 42 to 399 (358 residues), 183.7 bits, see alignment E=9.9e-58 PF01979: Amidohydro_1" amino acids 48 to 398 (351 residues), 61.6 bits, see alignment E=8.3e-21

Best Hits

Swiss-Prot: 58% identical to CODA_ECOLI: Cytosine deaminase (codA) from Escherichia coli (strain K12)

KEGG orthology group: K01485, cytosine deaminase [EC: 3.5.4.1] (inferred from 96% identity to pfs:PFLU2109)

MetaCyc: 71% identical to cytosine deaminase monomer (Klebsiella pneumoniae)
Cytosine deaminase. [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]; 3.5.4.1 [EC: 3.5.4.1]

Predicted SEED Role

"Cytosine deaminase (EC 3.5.4.1)" (EC 3.5.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UJ25 at UniProt or InterPro

Protein Sequence (411 amino acids)

>PS417_09800 cytosine deaminase (Pseudomonas simiae WCS417)
MHIINARLRNREGLHDLHLEHGRIASITPQTTAPVLASGDLDAAGNLVIPPFVEPHIHLD
ATLTAGEPRWNMSGTLFEGIECWGERKATITQEDTKTRAKKTIQALAAHGIQHVRTHVDV
TDPDLTALKAMLQVREESKHLIDLQIVAFPQEGIESYRNGRELMEEAIRLGADVIGGIPH
FEYTRDQGVSSVKFLMDLAERTGCLVDVHCDETDDPHSRFLEVLAEEARSRDMGARVTAS
HTTAMGSYDNAYCAKLFRLLGHSGISFVSCPTESIHLQGRFDSFPKRRGVTRVNELLEAG
MNVCFGQDSIVDPWYPLGNGNILRVLEAGLHICHMLGYRNLQSALDLVTDNSAKAMALGD
RYGLEPGRPANLLILSADSDYEVIRSQGLPLYSIRNGKVLMRRQPAQVEFV