Protein Info for GFF1922 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Lysine-specific permease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 25 to 43 (19 residues), see Phobius details amino acids 55 to 77 (23 residues), see Phobius details amino acids 91 to 114 (24 residues), see Phobius details amino acids 128 to 150 (23 residues), see Phobius details amino acids 162 to 186 (25 residues), see Phobius details amino acids 209 to 230 (22 residues), see Phobius details amino acids 243 to 266 (24 residues), see Phobius details amino acids 292 to 312 (21 residues), see Phobius details amino acids 338 to 359 (22 residues), see Phobius details amino acids 365 to 386 (22 residues), see Phobius details amino acids 410 to 431 (22 residues), see Phobius details amino acids 437 to 456 (20 residues), see Phobius details PF00324: AA_permease" amino acids 24 to 432 (409 residues), 321.1 bits, see alignment E=1.2e-99 PF13520: AA_permease_2" amino acids 25 to 434 (410 residues), 139.8 bits, see alignment E=1.2e-44

Best Hits

Swiss-Prot: 39% identical to MMUP_ECOLI: Probable S-methylmethionine permease (mmuP) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 99% identity to sec:SC2359)

MetaCyc: 39% identical to CP4-6 prophage; S-methyl-L-methionine transporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-486

Predicted SEED Role

"Lysine-specific permease" in subsystem YeiH

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>GFF1922 Lysine-specific permease (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MDTLQQSPPAEPEGGLRRNLKKRHLLMMSLGGTIGTGLFIGIAEPLSSVGPAGTLLAYLF
AGTIMLATMMCLGELSCAFPHSGSFQHYALMFMPSPCWSYTIGWLYWFSWVFSLAADLTA
AGFIAHQFFPAVPVYMFCLAILLILTAINLTSAKSFGECEYWLSAIKVFAIVLFICAGGV
MIYSLMGHSDWHPTLKTDGMWFPHGWEQIVVYMTIVIYSFQGVELVGNAAGETESPHIIL
PKVILGIGLRIILFYGLAIAVLALVYPHELTPNGQSPFVWVFSHAGIPGADTLMTLVIFS
AAVSAANSAIYASSRMLWSMAGDRFAPACFGKTNGGGVPVYAILITALLALVSLLTRYIP
AQQFYLYLIASTGQVGCLAWITIGWCQYRFRQSVRNGTYASDLLRYRSPLFPWTARFVII
TNFAIMVGTWFSEQGVVIMLVELAFMIGILLSWYLFRPTLSRLRNTVG