Protein Info for GFF1918 in Xanthobacter sp. DMC5

Annotation: GTPase Der

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 462 TIGR00231: small GTP-binding protein domain" amino acids 3 to 158 (156 residues), 82 bits, see alignment E=6.4e-27 amino acids 197 to 363 (167 residues), 84.9 bits, see alignment E=7.8e-28 PF02421: FeoB_N" amino acids 5 to 122 (118 residues), 44.8 bits, see alignment E=4.5e-15 amino acids 199 to 364 (166 residues), 40 bits, see alignment E=1.3e-13 PF01926: MMR_HSR1" amino acids 5 to 120 (116 residues), 98.1 bits, see alignment E=1.6e-31 amino acids 199 to 317 (119 residues), 76.8 bits, see alignment E=6.5e-25 TIGR03594: ribosome-associated GTPase EngA" amino acids 5 to 454 (450 residues), 529.8 bits, see alignment E=8.8e-163 PF00009: GTP_EFTU" amino acids 198 to 366 (169 residues), 30 bits, see alignment E=1.7e-10 PF14714: KH_dom-like" amino acids 374 to 454 (81 residues), 108 bits, see alignment E=1e-34

Best Hits

Swiss-Prot: 89% identical to DER_XANP2: GTPase Der (der) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K03977, GTP-binding protein (inferred from 89% identity to xau:Xaut_2545)

Predicted SEED Role

"GTP-binding protein EngA" in subsystem Universal GTPases

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (462 amino acids)

>GFF1918 GTPase Der (Xanthobacter sp. DMC5)
MTFSLAIVGRPNVGKSTLFNRLVGKKLALVDDRPGVTRDRREGEGRLGDLTFRIVDTAGL
EEATPASLEGRMRAQTEAAIGDCDAILFMIDARIGLTPTDRAFADLVRKAGKPVILVANK
SEGRGGEAGTLEAFGLGLGDPIPLSAEHGEGLSDLYDAICDALPEQTRLEEENEEEEDDA
DEVPVEGEVEPEKPRRPIKVAVLGRPNAGKSTLINKLLGEDRLLTGPEAGITRDSISVNV
TYAGIPLELFDTAGLRKRSRIDDKLEKLSAADALRAMKFAEVVVILIDATRPFEEQDLRI
ADLVAREGRALVIGYNKADLVPRGGLATRLREEIDHLLPQVKGVPIVPLSGLMGHGLDKL
VAAIASAHKVWNKRVATNPLNRFLQQVTENHPPPAVSGRRIKLRYMTQPKARPPSFVLFC
SRTDAVPESYIRYLVNGIRETFDLPGVPIRLTLREKDNPYAD