Protein Info for GFF1916 in Variovorax sp. SCN45

Annotation: YpfJ protein, zinc metalloprotease superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 295 transmembrane" amino acids 33 to 59 (27 residues), see Phobius details PF04228: Zn_peptidase" amino acids 1 to 290 (290 residues), 403.1 bits, see alignment E=4.1e-125

Best Hits

Swiss-Prot: 51% identical to YPFJ_ECO57: Uncharacterized protein YpfJ (ypfJ) from Escherichia coli O157:H7

KEGG orthology group: K07054, (no description) (inferred from 90% identity to vap:Vapar_3879)

Predicted SEED Role

"YpfJ protein, zinc metalloprotease superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (295 amino acids)

>GFF1916 YpfJ protein, zinc metalloprotease superfamily (Variovorax sp. SCN45)
MRWEGNEQSDNVEDRRGEGGGGGGGGFIGGRGIGIGTIAVALIAGWVFGINPLTVLGLLS
GGGPAQVQQQPQQGPAPKPPSNDREAAFVSTVLRNTEVVWTDIFKQNGGTYHPPRLVLFR
NATPTACGTGQSAMGPFYCPGDQKVYIDLGFYDTLKNQLGAPGEFAQAYVIAHEVGHHVQ
DELGITAKVDGMRNRLSQTQNNAMSVRVELQADCFAGVWAHHSQESKKWLDPGDIESAMN
AAQKIGDDALQRSAGRAVVPDSFTHGTSAQRQRWFGAGYQSGEIKACDTFNARSL