Protein Info for GFF1895 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Nucleotidase YfbR, HD superfamily

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF12917: YfbR-like
  • amino acids 5 to 186 (182 residues), 254.5 bits, E=8.3e-80
• PF13023: HD_3
  • amino acids 12 to 163 (152 residues), 56 bits, E=7.1e-19
• PF01966: HD
  • amino acids 30 to 141 (112 residues), 37.1 bits, E=5.2e-13

Best Hits

Swiss-Prot: 100% identical to 5DNU_SALA4: 5'-deoxynucleotidase YfbR (yfbR) from Salmonella agona (strain SL483)

KEGG orthology group: K08722, 5'-nucleotidase [EC: 3.1.3.5] (inferred from 100% identity to see:SNSL254_A2517)

MetaCyc: 92% identical to dCMP phosphohydrolase (Escherichia coli K-12 substr. MG1655)
RXN-14143 [EC: 3.1.3.89]; 3.1.3.89 [EC: 3.1.3.89]; 3.1.3.89 [EC: 3.1.3.89]; 3.1.3.89 [EC: 3.1.3.89]

Predicted SEED Role

"Nucleotidase YfbR, HD superfamily"

MetaCyc Pathways

• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• NAD salvage pathway III (to nicotinamide riboside) (2/3 steps found)
• adenosine nucleotides degradation II (3/5 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• guanosine nucleotides degradation I (2/4 steps found)
• guanosine nucleotides degradation II (2/4 steps found)
• guanosine nucleotides degradation III (2/4 steps found)
• ureide biosynthesis (4/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• NAD salvage (plants) (5/11 steps found)
• superpathway of purines degradation in plants (10/18 steps found)
• tunicamycin biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Nicotinate and nicotinamide metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.5

Use Curated BLAST to search for 3.1.3.5 or 3.1.3.89

Protein Sequence (199 amino acids)

>GFF1895 Nucleotidase YfbR, HD superfamily (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKQSHFFAHLSRMKLINRWPLMRNVRTENVSEHSLQVAMVAHALAAIKNRKFGGQLNAER
IALLAMYHDASEVLTGDLPTPVKYFNSQIAQEYKAIEKIAQQKLVDMAPDELRDIFAPLI
DENAWSEEEQAIVKQADALCAYLKCLEELSAGNNEFGLAKTRLEKTLELRRSQEMDYFMA
VFVPSFHLSLDEISQDSPL