Protein Info for GFF1890 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 654 transmembrane" amino acids 18 to 39 (22 residues), see Phobius details TIGR03423: penicillin-binding protein 2" amino acids 17 to 612 (596 residues), 732.8 bits, see alignment E=1.5e-224 PF03717: PBP_dimer" amino acids 61 to 237 (177 residues), 142.5 bits, see alignment E=2e-45 PF00905: Transpeptidase" amino acids 270 to 608 (339 residues), 220.6 bits, see alignment E=2.8e-69

Best Hits

KEGG orthology group: K05515, penicillin-binding protein 2 (inferred from 70% identity to vpe:Varpa_0296)

Predicted SEED Role

"Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129)" in subsystem Bacterial Cell Division or Bacterial Cytoskeleton or Flagellum in Campylobacter or Peptidoglycan Biosynthesis (EC 2.4.1.129)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.129

Use Curated BLAST to search for 2.4.1.129

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (654 amino acids)

>GFF1890 Cell division protein FtsI [Peptidoglycan synthetase] (EC 2.4.1.129) (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTEIRNVEADLAQFRTRALLIGLTVVFVFGLIASRMVYLQVVRHEDLAAQAESNRTAVLP
VVPNRGQILDRKGRILATNYSAYTLEITPSRVEDMDATIAGLSELVEVTPRDQRRFRKLL
EESHRFDSLPLRTRLTDVEVARFTAQRYRFPGVDVRARLLRQYPNGEVASHVIGYIGRIN
QRETELIADWPEEDQANYRGTEYIGKLGAEQSYERELHGITGFQRVETSAGGRAVRSLAN
TPATPGNAVVLSIDIQLQKLVEDMFGERRGALVAIDPRSGEVLAFVSKPTFDPNLFVEGI
DVENWRALNESMDKPLLNRALRGTYPPGSTYKPFMALAALETGSRSASMVMNDPGYWMFG
GHRFRSHGDGLGAVDMHRAIVKSSNTYFYSLANDMGVDAMHDFMKPLGFGQITGIDLKGE
VRGVLPSQAWKRNTYKRPEQQRWYAGETISLGIGQGYNNFTMLQIAHAMATLANGGIKYK
PHLTMATENVITRERVPLPGPPPENLGFKPENVRIVLNAMQAVTTEGTSTRVFAGAGYAS
GGKTGTAQAVTIGQKERYDARRLEEHQRDHSLYLAFAPVDQPRVALAVIVENAGFGAAHA
APIARRVFDYLLMDQYPNPQDLAAVRVGQAGAPIGTPLKASEQPWPPASMAPAP