Protein Info for GFF1868 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Naphthoate synthase (EC 4.1.3.36)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 TIGR01929: naphthoate synthase" amino acids 22 to 281 (260 residues), 500 bits, see alignment E=7.7e-155 PF00378: ECH_1" amino acids 31 to 279 (249 residues), 264.2 bits, see alignment E=1.1e-82 PF16113: ECH_2" amino acids 35 to 212 (178 residues), 84.8 bits, see alignment E=8.6e-28

Best Hits

Swiss-Prot: 100% identical to MENB_SALTY: 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01661, naphthoate synthase [EC: 4.1.3.36] (inferred from 100% identity to sec:SC2307)

MetaCyc: 97% identical to 1,4-dihydroxy-2-naphthoyl-CoA synthase (Escherichia coli K-12 substr. MG1655)
Naphthoate synthase. [EC: 4.1.3.36]

Predicted SEED Role

"Naphthoate synthase (EC 4.1.3.36)" in subsystem Menaquinone and Phylloquinone Biosynthesis (EC 4.1.3.36)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.3.36

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (285 amino acids)

>GFF1868 Naphthoate synthase (EC 4.1.3.36) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MIYPDETMLYAPVEWHDCSEGYTDIRYEKSTDGIAKITINRPQVRNAFRPLTVKEMIQAL
ADARYDDNVGVIILTGEGDKAFCAGGDQKVRGDYGGYQDDSGVHHLNVLDFQRQIRTCPK
PVVAMVAGYSIGGGHVLHMMCDLTIAAENAIFGQTGPKVGSFDGGWGASYMARIVGQKKA
REIWFLCRQYDAQQALDMGLVNTVVPLADLEKETVRWCREMLQNSPMALRCLKAALNADC
DGQAGLQELAGNATMLFYMTEEGQEGRNAFNQKRQPDFSKFKRNP