Protein Info for GFF1843 in Variovorax sp. SCN45

Annotation: Xanthine/uracil/thiamine/ascorbate permease family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 427 transmembrane" amino acids 15 to 35 (21 residues), see Phobius details amino acids 44 to 66 (23 residues), see Phobius details amino acids 79 to 115 (37 residues), see Phobius details amino acids 130 to 152 (23 residues), see Phobius details amino acids 163 to 181 (19 residues), see Phobius details amino acids 188 to 206 (19 residues), see Phobius details amino acids 231 to 255 (25 residues), see Phobius details amino acids 277 to 299 (23 residues), see Phobius details amino acids 311 to 328 (18 residues), see Phobius details amino acids 335 to 355 (21 residues), see Phobius details amino acids 373 to 396 (24 residues), see Phobius details amino acids 408 to 425 (18 residues), see Phobius details PF00860: Xan_ur_permease" amino acids 14 to 384 (371 residues), 207.2 bits, see alignment E=1.8e-65

Best Hits

Swiss-Prot: 54% identical to Y326_METJA: Putative permease MJ0326 (MJ0326) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K06901, putative MFS transporter, AGZA family, xanthine/uracil permease (inferred from 97% identity to vpe:Varpa_4511)

MetaCyc: 50% identical to adenine:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-447

Predicted SEED Role

"Xanthine/uracil/thiamine/ascorbate permease family protein" in subsystem Purine Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (427 amino acids)

>GFF1843 Xanthine/uracil/thiamine/ascorbate permease family protein (Variovorax sp. SCN45)
VFKLSAHNTTVRTEVIAGLTTFLTMAYIIFVNPSILGDAGMPKGAVFVATCLIAALGTLI
MGLYANYPIAMAPGMGLNAYFAYVVVLGMGYTWQVALGAVFISGCLFLIVTVTGLRELFI
QGIPQSLRTAITVGIGMFLALVALKGAGVVAASPATFVTLGDLHSPPVVLATLGFLLIVA
LDKLKVRGAILIGIITVTVLSFFFGGNKFHGVFDAPPSIAPTFMQLDILGALKGGILNVV
LVFFLVEMFDATGTLMGVAKRAGLLVPGKMERMNKALLADSGAIFAGSLLGTSSTTAYVE
SAAGVQAGGRTGLTAVVVALLFLACLMISPLAGSVPAYATAPALLFVGCLMLRDLVELDW
EDTTEVIPAAVTALAMPFTYSIANGLAFGFITYAVLKLCTGRAREVHAMVWVIAAVFLFK
FAYVGGH