Protein Info for GFF1838 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 761 PF03477: ATP-cone" amino acids 6 to 92 (87 residues), 50.2 bits, see alignment E=4.7e-17 PF00317: Ribonuc_red_lgN" amino acids 142 to 219 (78 residues), 56.2 bits, see alignment E=4.3e-19 TIGR02506: ribonucleoside-diphosphate reductase, alpha subunit" amino acids 145 to 735 (591 residues), 601.1 bits, see alignment E=1.2e-184 PF02867: Ribonuc_red_lgC" amino acids 223 to 731 (509 residues), 473.4 bits, see alignment E=1.4e-145

Best Hits

Swiss-Prot: 100% identical to RIR1_SALTY: Ribonucleoside-diphosphate reductase 1 subunit alpha (nrdA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K00525, ribonucleoside-diphosphate reductase alpha chain [EC: 1.17.4.1] (inferred from 97% identity to ecp:ECP_2277)

MetaCyc: 97% identical to ribonucleoside-diphosphate reductase 1 subunit alpha (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1)" in subsystem Ribonucleotide reduction (EC 1.17.4.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.17.4.1

Use Curated BLAST to search for 1.17.4.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (761 amino acids)

>GFF1838 Ribonucleotide reductase of class Ia (aerobic), alpha subunit (EC 1.17.4.1) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MNQSLLVTKRDGRTERINLDKIHRVLDWAAEGLNNVSVSQVELRSHIQFYDGIKTSDIHE
TIIKAAADLISRDAPDYQYLAARLAIFHLRKKAFGQFEPPALYHHVVKMVELGKYDNHLL
EDYTEEEFKQMDSFIVHDRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYILVAACL
FSNYPRETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINAT
SSAIVKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGG
AATLFYPMWHLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGGDITLFSPSD
VPGLYDAFFADQDEFERLYVKYEHDDSIRKQRVKAVELFSLMMQERASTGRIYIQNVDHC
NTHSPFDPVVAPVRQSNLCLEIALPTKPLNDVNDENGEIALCTLSAFNLGAIKTLDELEE
LAILAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYWLAKNGKRYSDGSANNLT
HKTFEAIQYYLLKASNELAKEQGACPWFNETTYAKGILPIDTYKKDLDAIVNEPLHYDWE
QLRESIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDYE
HLKDAYELLWEMPNNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKVPMQQLLKDLLT
AYKFGVKTLYYQNTRDGAEDAQDDLAPSIQDDGCESGACKI