Protein Info for GFF1825 in Xanthobacter sp. DMC5

Annotation: Sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1207 transmembrane" amino acids 20 to 41 (22 residues), see Phobius details amino acids 203 to 225 (23 residues), see Phobius details PF00672: HAMP" amino acids 222 to 265 (44 residues), 31.4 bits, see alignment (E = 7e-11) PF13185: GAF_2" amino acids 294 to 433 (140 residues), 55.9 bits, see alignment E=1.9e-18 PF01590: GAF" amino acids 295 to 433 (139 residues), 41.6 bits, see alignment E=6.5e-14 PF00512: HisKA" amino acids 540 to 607 (68 residues), 63.2 bits, see alignment 6.7e-21 PF02518: HATPase_c" amino acids 654 to 764 (111 residues), 98.4 bits, see alignment E=1.2e-31 PF00072: Response_reg" amino acids 829 to 937 (109 residues), 63.8 bits, see alignment E=5.6e-21 amino acids 951 to 1058 (108 residues), 67.5 bits, see alignment E=4e-22 amino acids 1089 to 1201 (113 residues), 92.3 bits, see alignment E=7.8e-30

Best Hits

Predicted SEED Role

"Signal transduction histidine kinase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1207 amino acids)

>GFF1825 Sensor histidine kinase RcsC (Xanthobacter sp. DMC5)
MLEKLTERSWFADLKMQTKAGLIVALLIAMFMLLFGANWVTGRMAQQQERRVETIRQVSV
LTADAMRAFNRRQLELLRSALADPRNLKARLAASTALTNEKLAALRAAVVAQPMLLPFAE
RAGRIAGRWVDAVAAPVLAASESGDPAAMDAALRVFLAAESSEEGYRGIIGALDELSAAA
SAEIVSAQADLDRADAIVGTIDIIALVATLCVAAAGVFLGAMFMARPLRRLAEQMTRLAE
NDRTIEVSYAERKDEVGTLARALKVFKATSIAAHDTDWVKSGLNNIAARLQSQEDPRDFA
DALLTELAPLLGAGVGVFYAHDESAGPEGSALELVGSYAFSERRHLSTRVRIGEGLVGQC
ALERKTIVLSPAPADHLRIRTGTGEASAHSIVAVPLVLKKRLLGVIELALLAPLEERARR
LLNEVAPLVALSLDNLVRAARTRELLEQSQKQAQELRVAEEELRTQQEELRATNEQLHER
SQRLAASEEELRVQADELQASNDVLRRSSQEMTAQKELLEALNQQMEARAGELLRANEYK
SQFLANMSHELRTPLNSLLILSQDLAENRTGNLDADQVEAASIIHSSGSNLLRLINDILD
LSKVEAGKMEVVYEPVKVASVAQRLERNFRRLAQERKLRLAVSVTDAPELVFTDPGKLDQ
ILTNLVGNALKFTMQGRVSVTFSKDEAGKTLKVAVADSGIGIPEDKLGAIFEAFEQVDAS
TRRQFGGTGLGLAITQRLARLLGGSVTVESALGQGSTFTLEIPVGEPLPEEDGEAAPAPA
PQPAMDARQVAFDTSRQAGEAAGLSGLPPVPAVNVEDDRDRLTPGATVILVVEDDPVFAR
TLVGLVRRKGYLALAAGDGESGLALARTYKPTGILLDVMLPGLDGWTVIERLKADAATRH
IPVHFVSALDESRRGRDLGAVGFLTKPVSADQLSEALGLLTHYSADRPRRVLVVDDDAAA
RHAVRTLLAREKAQIVEAASAEAALEVVAQGDLDCIVLDLGLPGMSGFELIERLADGGKH
VPVVVYSGRDLTTEERMKLRAFTDAIVVKGALSPERLLDEVSLFLHSVQREPEQLAANPD
GDLEGRKLLLVDDDMRNIYALAKVLRARGVNVVLAQDGAKALAQLDEQPDIEIVLMDVMM
PVMDGYEAMTQIRAQPRFAKLPVIALTAKAMKDDREKCLAAGASDYLAKPVDVPKLLSMI
RTWLAAR