Protein Info for GFF178 in Sphingobium sp. HT1-2

Annotation: Periplasmic chaperone and peptidyl-prolyl cis-trans isomerase of outer membrane proteins SurA (EC 5.2.1.8)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details PF09312: SurA_N" amino acids 63 to 176 (114 residues), 54.4 bits, see alignment E=3.6e-18 PF13624: SurA_N_3" amino acids 63 to 176 (114 residues), 40.4 bits, see alignment E=7.2e-14 PF13616: Rotamase_3" amino acids 201 to 304 (104 residues), 57.6 bits, see alignment E=4.7e-19 PF00639: Rotamase" amino acids 217 to 302 (86 residues), 68.8 bits, see alignment E=1.7e-22

Best Hits

KEGG orthology group: K03771, peptidyl-prolyl cis-trans isomerase SurA [EC: 5.2.1.8] (inferred from 84% identity to sjp:SJA_C1-25540)

Predicted SEED Role

"Survival protein SurA precursor (Peptidyl-prolyl cis-trans isomerase SurA) (EC 5.2.1.8)" in subsystem Peptidyl-prolyl cis-trans isomerase (EC 5.2.1.8)

Isozymes

Compare fitness of predicted isozymes for: 5.2.1.8

Use Curated BLAST to search for 5.2.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (454 amino acids)

>GFF178 Periplasmic chaperone and peptidyl-prolyl cis-trans isomerase of outer membrane proteins SurA (EC 5.2.1.8) (Sphingobium sp. HT1-2)
MLSVVFSPKSVRSGLRTLFLSTALLGMAAQTVSAQAVDDDADQGLNLPKDVTIFGKNDPN
VRKATAIVNGRIITGTDVDQRLALIITANGGKVSAEEKERLRVQVLRNLIDETLQIQEAA
ANDIKIDPAEVNQSYERVAANFRKSPPQFDQYLREQGSSASSIKRQIEGELAWSRLLRRN
IQPFVNVSEDEVKSVVDRLNAAKGSDEVRISEIYLSSTPENRDQITANARNIIEQIKQGG
SFAAYARQFSEASTAVVGGDLGWVRPSQLPTELAQAATELQVGQLAGPIETVGGMSIIYV
MDKRKVLTADPRDSLLSLKQLSVLFPAGTSKEAASQKAATFAAAVKEIKGCGQANEIGAR
IGADVVDNDNVKLRDLPPQLQDILVNLQVGESTPPFGSINDGVRVLIVCGRDEPQSANAP
NPEQIQAQLEEERVNKRARIYLRDLRRDAVIEYN