Protein Info for GFF1769 in Hydrogenophaga sp. GW460-11-11-14-LB1
Annotation: Uroporphyrinogen III decarboxylase (EC 4.1.1.37)
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 83% identical to DCUP_POLSJ: Uroporphyrinogen decarboxylase (hemE) from Polaromonas sp. (strain JS666 / ATCC BAA-500)
KEGG orthology group: K01599, uroporphyrinogen decarboxylase [EC: 4.1.1.37] (inferred from 83% identity to pol:Bpro_4264)MetaCyc: 59% identical to uroporphyrinogen decarboxylase (Escherichia coli K-12 substr. MG1655)
Uroporphyrinogen decarboxylase. [EC: 4.1.1.37]
Predicted SEED Role
"Uroporphyrinogen III decarboxylase (EC 4.1.1.37)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 4.1.1.37)
MetaCyc Pathways
- superpathway of heme b biosynthesis from glutamate (9/10 steps found)
- superpathway of heme b biosynthesis from glycine (6/8 steps found)
- heme b biosynthesis I (aerobic) (3/4 steps found)
- heme b biosynthesis II (oxygen-independent) (3/4 steps found)
- heme b biosynthesis V (aerobic) (3/4 steps found)
- superpathway of heme b biosynthesis from uroporphyrinogen-III (4/6 steps found)
- heme b biosynthesis IV (Gram-positive bacteria) (1/5 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis I (aerobic, light-dependent) (3/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) (3/9 steps found)
- 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) (3/9 steps found)
- superpathway of bacteriochlorophyll a biosynthesis (6/26 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.37
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (367 amino acids)
>GFF1769 Uroporphyrinogen III decarboxylase (EC 4.1.1.37) (Hydrogenophaga sp. GW460-11-11-14-LB1) MPFAPLQNDSFLRACLRQSTEHTPVWLMRQAGRYLPEYRATRAQAGSFMGLATNTDYATE VTLQPLERYALDAAILFSDILTVPDAMGLGLSFALGEGPKFEKTVRTEADVAALAVPDMD KLRYVFDAVTSIRKALNGRVPLIGFSGSPWTLACYMVEGGGSDDYRAVKSLMYARPDLMH RILAVNADAVATYLNAQIEAGAQAVMVFDSWGGVLADGKFQDFSLAYTRRVLAQLKREHE GVVIPRIVFTKGGGLWLDDMKDLDCHALGLDWTVNLARARAQVGEGPGGKALQGNIDPNV LFAPPERIEAEVAAVLESFGRPHQGAGTGPTHIFNLGHGISQHTPPEHVSVLVDAVHSHS RRLRQGA