Protein Info for GFF1721 in Xanthobacter sp. DMC5
Annotation: Homoserine kinase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 88% identical to KHSE_XANP2: Homoserine kinase (thrB) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)
KEGG orthology group: K02204, homoserine kinase type II [EC: 2.7.1.39] (inferred from 88% identity to xau:Xaut_2356)Predicted SEED Role
"Homoserine kinase (EC 2.7.1.39)" in subsystem Methionine Biosynthesis or Threonine and Homoserine Biosynthesis (EC 2.7.1.39)
MetaCyc Pathways
- aspartate superpathway (22/25 steps found)
- superpathway of L-isoleucine biosynthesis I (13/13 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (15/18 steps found)
- superpathway of L-threonine biosynthesis (6/6 steps found)
- superpathway of L-lysine, L-threonine and L-methionine biosynthesis II (12/15 steps found)
- L-threonine biosynthesis (2/2 steps found)
- L-methionine biosynthesis II (4/6 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 2.7.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (321 amino acids)
>GFF1721 Homoserine kinase (Xanthobacter sp. DMC5) VAVYTDVAPAELEAFLSGYDIGSLTSFHGIAEGVENSNFLVQTTTGSYILTLYEKRVRRE DLPFFVGLMQHLAARGLSCPEPVAARSGAILAEVAGRPAAMVTFLPGVSVRRPTAHHCAE LGRGLAQLHLAGADFPLKRANALSVAGWRPLFEAAGAAADTVAPGLSDAVAAELAVLEAN WPQDLPSGVIHADLFPDNAFFLDDQLSGIIDFYFACTDFLAYDVAICLNAWCFEADGAYN VTKGRALLAGYEAVRPLSEDEKAALPRLARGAALRFLLTRLVDWLNVPEGALVRPKDPLE YLKKLRFHQAVERAQDYGLAA