Protein Info for GFF1719 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Potassium uptake protein TrkH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 transmembrane" amino acids 7 to 28 (22 residues), see Phobius details amino acids 40 to 59 (20 residues), see Phobius details amino acids 71 to 93 (23 residues), see Phobius details amino acids 134 to 162 (29 residues), see Phobius details amino acids 184 to 204 (21 residues), see Phobius details amino acids 239 to 258 (20 residues), see Phobius details amino acids 278 to 296 (19 residues), see Phobius details amino acids 333 to 358 (26 residues), see Phobius details amino acids 397 to 426 (30 residues), see Phobius details amino acids 457 to 481 (25 residues), see Phobius details PF02386: TrkH" amino acids 43 to 484 (442 residues), 213.2 bits, see alignment E=2.9e-67

Best Hits

Swiss-Prot: 44% identical to TRKH_SALTY: Trk system potassium uptake protein TrkH (trkH) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03498, trk system potassium uptake protein TrkH (inferred from 61% identity to lch:Lcho_4071)

MetaCyc: 43% identical to K+ transporter TrkH (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-3

Predicted SEED Role

"Potassium uptake protein TrkH" in subsystem Potassium homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (486 amino acids)

>GFF1719 Potassium uptake protein TrkH (Hydrogenophaga sp. GW460-11-11-14-LB1)
VYSLLPVLAVFSRILLAFSPAFLVPLAWSWFFDAHHHTRVWAYGFALTVGSGVVLWRLTR
QFRRELQARDGFLLVNLVWTLLPAFAAVPLMFTVPGIDWTKAYFESMSALTATGATALSN
LDALPVSVNIWRCFLQLVGGLGIVLLVVAVLPLLGLGGVQLYRAETPGPMKDTKFTPRIA
ETARGLWGVYVLFSVACMLSYRWAGMTWADAFMHMCTTMGLGGFSSHDASFGYWDSPRID
AVATVFMALAGVSFLRYFMVLRQRSLRPIVNDREIRTYVAVLLVSILLVAVLLAVHRQTD
SFMEAFRVSAFHVVSVATTTGYASTDYEQWPVFAPVLMMFLGCFVSCAGSTGGGIKLVRM
VLLIKQARRELVRIIHPRVVNPVTLGGMVMPPAVMNAVLGYMLIYGAATMGLTMVLLFTG
LDIVTAFSAVVATVNNIGPGLGEVGPSSNFGVLDDFQIWVLSFAMLLGRLELLTVLVLFT
GHFWKK