Protein Info for GFF17 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: LysR family transcriptional regulator YfeR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 transmembrane" amino acids 241 to 247 (7 residues), see Phobius details PF00126: HTH_1" amino acids 5 to 64 (60 residues), 83.8 bits, see alignment E=6.4e-28 PF03466: LysR_substrate" amino acids 91 to 293 (203 residues), 161.2 bits, see alignment E=2.3e-51

Best Hits

Swiss-Prot: 52% identical to YFER_SHIFL: Uncharacterized HTH-type transcriptional regulator YfeR (yfeR) from Shigella flexneri

KEGG orthology group: None (inferred from 69% identity to adk:Alide2_3731)

Predicted SEED Role

"LysR family transcriptional regulator YfeR" in subsystem DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (300 amino acids)

>GFF17 LysR family transcriptional regulator YfeR (Hydrogenophaga sp. GW460-11-11-14-LB1)
MNVSLRQLRVFQAVASHGSFTRAGEHIGLSQPAVSRCVTELEQHLGLKLLDRTTREVVLT
DAGRGLAVQLGRVLEDLDALLQESRGQALRPHGRVRVASSPTLSANLLPECIARCQHEHP
GLALLLLDRIQHDTLASVLAGEVDFGVVIDPGPRGDLHAEAVLSEPFCLVCPPTHRLARR
RNARWTDLAGESLVLLDHASGSRRLIDDALRAHGVEASVAQEVGHVTTIFRMLDAGLGIS
VVPVLALPPAGLQGLVMRPLLPRIERQVALVRRSNRTLTPAADMVWQLVRRVAAERATRP