Protein Info for PS417_08580 in Pseudomonas simiae WCS417

Annotation: histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 769 transmembrane" amino acids 16 to 38 (23 residues), see Phobius details amino acids 161 to 183 (23 residues), see Phobius details PF00512: HisKA" amino acids 287 to 351 (65 residues), 69.6 bits, see alignment E=2.9e-23 PF02518: HATPase_c" amino acids 397 to 507 (111 residues), 96.4 bits, see alignment E=2.2e-31 PF00072: Response_reg" amino acids 648 to 756 (109 residues), 97.5 bits, see alignment E=8.1e-32

Best Hits

KEGG orthology group: None (inferred from 96% identity to pfs:PFLU1736)

Predicted SEED Role

"sensor histidine kinase/response regulator"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U724 at UniProt or InterPro

Protein Sequence (769 amino acids)

>PS417_08580 histidine kinase (Pseudomonas simiae WCS417)
MDIKFAHRLSYKQARLTVLVGFVLGTLLSLIQIGIDYASEDASINREIRSLIEISHNPAS
RIAYNIDAELAQELTLGLLHSPAIIHAQLIDNNGVVLADVDRPRKESSYRPVSDFLFGAN
RQFEDRLFLSHMPNESLGVLRLDVDTYAFGSRFLRRAEVTLLNGFVRSLLLTGILLGLFY
VMLTQPLVRIIRELSNRKQARLDCPPGHEHDEIGVLVNVANQQFENMETEIQQRRHAEDR
LTEYLGQLEDIVSARTLELKASNQRLSQSNDELEAAKMHALGMAQARAAFLANMSHEIRT
PLNGLLGMIALSLDSPLNAEQRQQLSIAHDSGKVLVELLNDILDLSKFDAGQLELERIPF
DLGSLVEDTANLLSQNAAPSVELTCLIDPQFPAQVLGDPTRVRQIVSNLLSNALKFTRFG
RVDVRLSAHEGQVRIEVCDTGIGIAQEAQVKIFQPFTQAGAGITRQFGGTGLGLALTHNL
CEAMKGRLSISSEVGFGSQFCADLPLPTHLPAIQPAPLKGEVIAITSTGSGLTELLTTLL
PHWGLTPRCYPRDEDLSGQTPDLLITDCPECLFRLRPTITAPILVVTAYGNFMPSEEVAA
LAPLQQQARPLSRNALYQILQRNLRSDAQLILDPIQMETAPLVHRARILLVEDNPVNQLV
AKGMLSKLGCEVIVAAHGGEALKFLEEQHFDLVLMDCNMPVMDGYEASRQIRRSGRWPDL
PIVALTANALSEERERCRAAGMNDYLAKPFRREELSGLLELWVPKTTSL