Protein Info for PS417_08575 in Pseudomonas simiae WCS417

Annotation: MarR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 159 PF22381: Staph_reg_Sar_Rot" amino acids 25 to 109 (85 residues), 64 bits, see alignment E=2.2e-21 PF12802: MarR_2" amino acids 34 to 96 (63 residues), 36.9 bits, see alignment E=6.7e-13 PF01047: MarR" amino acids 35 to 98 (64 residues), 54.3 bits, see alignment E=2e-18 PF13463: HTH_27" amino acids 58 to 106 (49 residues), 29.7 bits, see alignment E=1.3e-10

Best Hits

Swiss-Prot: 36% identical to MGRA_STAA8: HTH-type transcriptional regulator MgrA (mgrA) from Staphylococcus aureus (strain NCTC 8325)

KEGG orthology group: None (inferred from 96% identity to pfs:PFLU1735)

Predicted SEED Role

"Organic hydroperoxide resistance transcriptional regulator" in subsystem Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UF74 at UniProt or InterPro

Protein Sequence (159 amino acids)

>PS417_08575 MarR family transcriptional regulator (Pseudomonas simiae WCS417)
MTVSLALDNQLCFKLYAASRAVTRAYKPMLDQLGLTYPQYLVMLVLWEWHAATPAQPTVK
ALGERLMLDSGTLTPLLKRLEQLGLVKRQRSAKDEREVHLSLSETGVQLRDQAHGLKTRL
LCDSGIDLNQADALRDGLDQLLRQIRDLSSSAPTAPAGH