Protein Info for GFF1643 in Xanthobacter sp. DMC5

Annotation: ADP-ribose pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 205 transmembrane" amino acids 167 to 189 (23 residues), see Phobius details TIGR00052: nudix-type nucleoside diphosphatase, YffH/AdpP family" amino acids 31 to 190 (160 residues), 94.4 bits, see alignment E=3.3e-31 PF00293: NUDIX" amino acids 50 to 167 (118 residues), 54 bits, see alignment E=9.5e-19

Best Hits

KEGG orthology group: K01515, ADP-ribose pyrophosphatase [EC: 3.6.1.13] (inferred from 78% identity to xau:Xaut_2637)

Predicted SEED Role

"ADP-ribose pyrophosphatase (EC 3.6.1.13)" in subsystem NAD and NADP cofactor biosynthesis global or Nudix proteins (nucleoside triphosphate hydrolases) (EC 3.6.1.13)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.1.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (205 amino acids)

>GFF1643 ADP-ribose pyrophosphatase (Xanthobacter sp. DMC5)
MEDRPARVDMDGPELLARGFRPYERYQLVLHHPDGTSDHQVRDIVRGGQVVGVLGYDPAR
DLVVLIRQFRLAAHLADGKGDLVEIVAGMVEQGEDPEAAARRECEEEAGVAPRALVPMLA
FTPTPGLTDEYARLYLGILDASRLPERAGSAAETETTRPFAVPVEEALAAIGAGRCINAF
LILALQWLALNRARLPELIAAAERG