Protein Info for GFF1637 in Variovorax sp. SCN45
Annotation: Polyketide synthase modules and related proteins
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Predicted SEED Role
"Malonyl CoA-acyl carrier protein transacylase (EC 2.3.1.39)" in subsystem Fatty Acid Biosynthesis FASII or mycolic acid synthesis (EC 2.3.1.39)
MetaCyc Pathways
- superpathway of fatty acids biosynthesis (E. coli) (48/53 steps found)
- superpathway of fatty acid biosynthesis II (plant) (38/43 steps found)
- superpathway of fatty acid biosynthesis I (E. coli) (14/16 steps found)
- fatty acid biosynthesis initiation (type II) (3/3 steps found)
- superpathway of fatty acid biosynthesis initiation (4/5 steps found)
- fatty acid biosynthesis initiation (mitochondria) (2/4 steps found)
- fatty acid biosynthesis initiation (plant mitochondria) (1/4 steps found)
- mycobactin biosynthesis (4/11 steps found)
- pederin biosynthesis (2/14 steps found)
- bryostatin biosynthesis (2/19 steps found)
- mupirocin biosynthesis (1/26 steps found)
- corallopyronin A biosynthesis (2/30 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.3.1.39
Use Curated BLAST to search for 2.3.1.39
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
Find the best match in UniProt
Protein Sequence (1532 amino acids)
>GFF1637 Polyketide synthase modules and related proteins (Variovorax sp. SCN45) MSDGTESGEVNEIDIAIVGLAGRYPGAPDVDAFWRNIRSGIESVSFFSDEELRDRGVPPE ALADPDYVKAGVVLDGMDRFDAGFFGYSAREAEYLDPQQRFFLETAVEALEHAGCYGDRQ PRRIGIYGGASTNQYAWRNLLSAGVLGGKGEEASLQTLLNGNEKDALCTRVAYELNLQGP AVTVQTACSTSLVAVHMACQALLNHEADMTLAGGVSLNLGQGLGYRYQAGSIASPDGHCR AFDARAAGTVSGSGVGIVAMKRLADALADGDTIHAVIKGSAINNDGSAKVGYTAPSVEGQ AQAILSAQMIADVSPDSIGYIEAHGTGTPMGDPIEIAALTQAFRTETERTGYCAIGSVKT NIGHLDAAAGVTGLIKAVLALRHKTLPPSLHYERPNPQIDFAGSPFYVNTEAKDWPAGRA PRRAGVSSFGMGGTNAHVVLEEAPVPVPSVAGRTWQVLPVSARSADAARAAQTRLARHVA QNEGQSLADVAWTLQTGRRHFAHRRAVLASTEAEAAFYLDAPDATHGWTGVCPAEAPQVA FLFPGQGAQHLHMGRMLYESEPLFRDVIDQCCRVLQPVLGLDLRQCLFPSETDQVAATEK LSQTAITQPALFVVEYAMARLWMHWGVQPAVMLGHSVGEYVAACIAGVFGLEDALTLIAA RGRLMQSLPRGEMMAVAMSEAELQPWLSSDCSLAAVNDDRLCVLSGTPEAIAAVERELTA RGTVARRLHVSHAFHSAMVEPVLPAFEALVEGVRRNAPSIPFISNVTGRPITDAEATSAQ YWVRHLRGTVRFADGLGELLRTPGRVLVEAGPGEVLVSLARRHVDAASAACIVASQTRPQ QWRQGDAQCARALAQMWVAGVPVDWQAYHGGASRRHVPLPTYPFESRSYWVAPGQTAPVA SARAQSRPAQRELADWFHVPAWRRAQPLSQAAVEIAEAGYCLVLGDAGDFRAALLQKLAV SPRPVVVVESASAFEVADAQHYRARTDAREDLARVLREAGSAHGPLRQVYHLWSLEAHDA HGPLEPVLARGFHSMLALAQALYGEGVASHGARLRVTVVASQLEDVTGLESLHPGKAMLH GPCKVLPQEFPDIACQLIDVAVPVNDDAALARLAGQVLAESRAAEPSALAAYRGPHRWQQ VFEPAPGGDGHQGRRLRKQGVYLITGGLGGIGLALAGHLAREWQARLVLVGRSEIPARHL WGEAIADPSTAPAQRERLQKLTQLSQAGAEVLVLQADVADARRMQEVVREAVAKFGNLHG VIHAAGLPGGGVMAQRERADADAVCKPKVQGTRALMAALAGHAPDFVLFCSSTAAAFGAF GDADYCSANCYLDATARLALREQRFPVWSVNWDTWREVGMAAHRDHPEGVGISPDMGARA FERVLCGEVAPQLFVSPLSVEEKRARLTSLDFEVESPAEAMRGVVGGSHERPTLATPFAP PETELEADIAQTWCEALGFSSIGVNDSLFELGGDSLTAIQLLGRVRKKFGVALHPAALFN EPTVAALAALVELHVIEQIEQAGVAGQVERVA