Protein Info for GFF1610 in Variovorax sp. SCN45

Annotation: Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 21 to 479 (459 residues), 566.2 bits, E=2.4e-174
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 32 to 477 (446 residues), 675.5 bits, E=1.9e-207

Best Hits

Swiss-Prot: 58% identical to GABD_ECOLI: Succinate-semialdehyde dehydrogenase [NADP(+)] GabD (gabD) from Escherichia coli (strain K12)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 76% identity to reu:Reut_B5660)

MetaCyc: 58% identical to succinate-semialdehyde dehydrogenase (NADP+) GabD (Escherichia coli K-12 substr. MG1655)
SUCCSEMIALDDEHYDROG-RXN [EC: 1.2.1.79]; Glutarate-semialdehyde dehydrogenase. [EC: 1.2.1.79, 1.2.1.20]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16)

MetaCyc Pathways

• TCA cycle IV (2-oxoglutarate decarboxylase) (8/9 steps found)
• superpathway of 4-aminobutanoate degradation (3/3 steps found)
• 4-aminobutanoate degradation II (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• L-lysine degradation X (4/6 steps found)
• 4-hydroxyphenylacetate degradation (5/8 steps found)
• L-lysine degradation IV (2/5 steps found)
• L-lysine degradation I (3/7 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)
• L-lysine degradation III (1/6 steps found)
• nicotine degradation II (pyrrolidine pathway) (2/11 steps found)
• nicotine degradation I (pyridine pathway) (5/17 steps found)
• superpathway of L-lysine degradation (12/43 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Lysine degradation
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.16

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.20 or 1.2.1.79

Protein Sequence (488 amino acids)

>GFF1610 Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16) (Variovorax sp. SCN45)
MHVQLEDMALWRRQSYIDGQWRDARSGKTLDVVNPASRQVLGTIASCDGVDTRDAIEAAH
AALPGWRSLTAHDRATLLLRWHELMLAHADDLALLMTLEQGKPLSESKGEVLYGASFVQW
FAAEGVRAYGETIPAAQSSRRIFVRKMPVGVCAAITPWNFPNAMITRKLAPALAAGCTVV
VKPSELTPYSALALAELGERAGFPKGVLNIVTGSPEGIGAELTGNPSVRKLTFTGSTAVG
KKLLRQCADTVKRVSLELGGNAPVIVFNDADFETAIAGVMTSKFRNSGQTCVCANRIYVQ
SGIYERFAERLVKEVQKLRVGAGTEPGIAIGPLINEGARRKVETHVEDALAKGASLASGG
KSSGLGTQFFEPTVLTEADDTMVLAHEETFGPVAALFRFATESEVLRRANDSPYGLAAYV
FSNDVSRLFRVSESLECGMVGMNTGAISTAVAPFGGVKESGLGREGSRHGIEEFLEVQTL
HLDLAGEA