Protein Info for PS417_08175 in Pseudomonas simiae WCS417

Annotation: UDP-N-acetylglucosamine 2-epimerase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00236: UDP-N-acetylglucosamine 2-epimerase
  • amino acids 4 to 363 (360 residues), 217.6 bits, E=1.4e-68
• PF02350: Epimerase_2
  • amino acids 27 to 361 (335 residues), 308.6 bits, E=2.4e-96

Best Hits

KEGG orthology group: K01791, UDP-N-acetylglucosamine 2-epimerase [EC: 5.1.3.14] (inferred from 86% identity to pen:PSEEN1502)

MetaCyc: 80% identical to UDP-2-acetamido-2,6-dideoxy-beta-L-talose 2-epimerase (Pseudomonas aeruginosa O11)
RXN-14761 [EC: 5.1.3.28]

Predicted SEED Role

"UDP-N-acetylglucosamine 2-epimerase (EC 5.1.3.14)" in subsystem CMP-N-acetylneuraminate Biosynthesis or Sialic Acid Metabolism (EC 5.1.3.14)

MetaCyc Pathways

• UDP-N-acetyl-α-D-mannosamine biosynthesis (1/1 steps found)
• UDP-N-acetyl-β-L-fucosamine biosynthesis (2/4 steps found)
• CMP-N-acetylneuraminate biosynthesis II (bacteria) (1/3 steps found)
• CMP-N-acetylneuraminate biosynthesis I (eukaryotes) (1/5 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (9/24 steps found)
• superpathway of CMP-sialic acids biosynthesis (1/15 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Nucleotide sugars metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 5.1.3.14 or 5.1.3.28

Sequence Analysis Tools

See A0A1N7TXD9 at UniProt or InterPro

Protein Sequence (376 amino acids)

>PS417_08175 UDP-N-acetylglucosamine 2-epimerase (Pseudomonas simiae WCS417)
MKKMKVVTVVGTRPEIIRLSRVIAKLDEHCEHILVHTGQNYDYELNEIFFQDLGIRKPDH
FLNAAGASGAQTIGNVIIAVDQVLEEVKPEALLILGDTNSCMAVIPAKRRKIPTFHMEAG
NRCFDMRVPEEINRRIVDHTADINLTYSSIARDYLLSEGLPPDRVIKTGSPMFEVLNYYR
DGIEASDVLGRLDLEAGKFFVVSAHREENIDSDKNFLKLVEVLNTVAAHYDLPVIVTTHP
RTQKRVDAMGVSFHKNVQLLKPLGFKDYNKLQLTAKVVLSDSGTINEESSILNFPALNLR
EAHERPEGMEEAAVMMVGLEVERAMQGLQLLESQAAGQERTLRLVADYSMPNVAEKVVRI
IHSYRDYVMRTVWKQY