Protein Info for GFF1588 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 354 transmembrane" amino acids 97 to 118 (22 residues), see Phobius details amino acids 123 to 143 (21 residues), see Phobius details amino acids 148 to 171 (24 residues), see Phobius details amino acids 192 to 219 (28 residues), see Phobius details amino acids 271 to 291 (21 residues), see Phobius details amino acids 302 to 323 (22 residues), see Phobius details PF00528: BPD_transp_1" amino acids 163 to 329 (167 residues), 96.7 bits, see alignment E=7.4e-32

Best Hits

Swiss-Prot: 100% identical to PROW_SALTY: Glycine betaine/proline betaine transport system permease protein ProW (proW) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02001, glycine betaine/proline transport system permease protein (inferred from 99% identity to sew:SeSA_A2958)

MetaCyc: 91% identical to glycine betaine ABC transporter membrane subunit ProW (Escherichia coli K-12 substr. MG1655)
RXN-8638 [EC: 7.6.2.9]; 7.4.2.- [EC: 7.6.2.9]

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 7.6.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (354 amino acids)

>GFF1588 L-proline glycine betaine ABC transport system permease protein ProW (TC 3.A.1.12.1) (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MADQTNPWDTAQVADTTTQTADAWGTPAGVATDGGSTDWLNSAPAPAPEHFSLLDPFHKT
LIPLDSWVTEGIDWVVTHFRPLFQGIRVPVDYILNGFQQLLLGMPAPVAIILFALIAWQV
SGVGMGIATLISLIAIGAIGAWSQAMITLALVLTALLFCVVIGLPMGIWLARSPRAAKIV
RPLLDAMQTTPAFVYLVPIVMLFGIGNVPGVVVTIIFALPPIVRLTILGINQVPADLIEA
SRSFGASPRQMLFKVQLPLAMPTIMAGVNQTLMLALSMVVIASMIAVGGLGQMVLRGIGR
LDMGLATVGGVGIVILAIILDRLTQAVGRDSRSRGNRRWYTTGPVGLITRPFVK