Protein Info for GFF1423 in Sphingobium sp. HT1-2

Annotation: Aromatic hydrocarbon utilization transcriptional regulator CatR (LysR family)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 291 transmembrane" amino acids 226 to 246 (21 residues), see Phobius details PF00126: HTH_1" amino acids 3 to 62 (60 residues), 74.2 bits, see alignment E=6.3e-25 PF03466: LysR_substrate" amino acids 87 to 276 (190 residues), 112.3 bits, see alignment E=2.2e-36

Best Hits

Swiss-Prot: 67% identical to ILVR_CAUVC: HTH-type transcriptional regulator IlvR (ilvR) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: None (inferred from 69% identity to swi:Swit_4657)

Predicted SEED Role

"Aromatic hydrocarbon utilization transcriptional regulator CatR (LysR family)" in subsystem DNA-binding regulatory proteins, strays

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (291 amino acids)

>GFF1423 Aromatic hydrocarbon utilization transcriptional regulator CatR (LysR family) (Sphingobium sp. HT1-2)
MDLRPLRHFLAVADTLHFGQAAQRLGMTQPPLSQSILALERELGAPLFIRSKRNVALTAF
GRQWLEHVRPAVEAVSALPDIARRLRDGSAGQIGLSFVSTADYSLLPALVRDYAARFPEV
EIALTEATSDVQIADLIDGVNDAGILIAPDGALPDALAYMPLLREPLVVAVPEGWVADDQ
AQGDPWLDRPLILFPRRVAPAFHDLVSGYLAGRGQPLLIRQEAIQMQTIISLVSAGMGIA
LVPASLRNLARTGVRYLDLQDAPILETGLAWRRDDDGATLAGLLGVARAMA