Protein Info for GFF1414 in Variovorax sp. SCN45

Annotation: Circadian clock protein KaiC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 PF06745: ATPase" amino acids 15 to 238 (224 residues), 152.5 bits, see alignment E=3.1e-48 amino acids 256 to 473 (218 residues), 77.3 bits, see alignment E=2.9e-25

Best Hits

KEGG orthology group: K08482, circadian clock protein KaiC (inferred from 82% identity to vpe:Varpa_2784)

Predicted SEED Role

"Circadian clock protein KaiC" in subsystem Cyanobacterial Circadian Clock

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (500 amino acids)

>GFF1414 Circadian clock protein KaiC (Variovorax sp. SCN45)
MTNPLEPVIPRNVEPTGVPGLDDVTAGGLPGGHVYLVEGTPGAGKTTLGLQFLLQGRSLG
QKGLYVTLSETSEELAQGAASHGWDLAGVEIFDLVSDDDLSAEAEQSILQPSDFELGETI
RGVMALVEREKPSRVVFDSLSELRLLSQSSLRYRRQILALKRFFLKHGCTVLLLDDKSAA
SGDMHLHSIAHGVIQLEQNTGTYGPDKRRMRVVKLRGVSFREGEHDFTLTRGGLRVFTRL
VANEHGRTHAQEPLSSGNPDLDRLLGGGLTPGTNLLFAGPAGVGKTTTAVSCVRASLQLG
GKAAIFLFDEGTKTLLTRSRALGMGIDEYIANGQLTLNSVDPAEISAGQFSHHVRDAVER
QGVTTVVIDTLNAYLVAMPGNNFLLLQMHELLTYLNLQGITTIVVLSQHGLTGETPNDVD
LSYLSDSMLQFRYFEARGELLKAVSVVKSRTSAHATTIHQFRLGQGGLEIGEALTDFEGV
MAGLPRYRGRTRLLGDADEA