Protein Info for GFF1408 in Xanthobacter sp. DMC5

Annotation: Multidrug resistance protein MdtB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1045 signal peptide" amino acids 1 to 29 (29 residues), see Phobius details transmembrane" amino acids 335 to 353 (19 residues), see Phobius details amino acids 360 to 382 (23 residues), see Phobius details amino acids 388 to 411 (24 residues), see Phobius details amino acids 431 to 455 (25 residues), see Phobius details amino acids 463 to 490 (28 residues), see Phobius details amino acids 528 to 547 (20 residues), see Phobius details amino acids 860 to 878 (19 residues), see Phobius details amino acids 885 to 905 (21 residues), see Phobius details amino acids 911 to 936 (26 residues), see Phobius details amino acids 957 to 976 (20 residues), see Phobius details amino acids 988 to 1015 (28 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1013 (1008 residues), 1038.8 bits, see alignment E=0 PF03176: MMPL" amino acids 265 to 489 (225 residues), 32.8 bits, see alignment E=3.8e-12

Best Hits

Swiss-Prot: 53% identical to MDTB_PECAS: Multidrug resistance protein MdtB (mdtB) from Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)

KEGG orthology group: None (inferred from 82% identity to azc:AZC_2425)

MetaCyc: 52% identical to multidrug efflux pump RND permease subunit MdtB (Escherichia coli K-12 substr. MG1655)
TRANS-RXN-352; TRANS-RXN-353; TRANS-RXN-92

Predicted SEED Role

"Acriflavin resistance protein" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1045 amino acids)

>GFF1408 Multidrug resistance protein MdtB (Xanthobacter sp. DMC5)
MNVSAPFIRRPIATTLLMAALLLVGLVAYPLLPVAPLPQVDFPTIQVSASLPGASPETMA
SSVATPLERQFSQIAGVTQMTSTSALGVAAITIQFDLGRSIDAAAQDVQSAINAASGQLP
KNLPSPPTFRKINPADAPILILSVQSDLYPLTKLDDSADTILAQQMSQIPGIAQVAITGE
QKPAVRVQVDPAKIAALGMSLEDVRAVLAAATVDQPKGSFDGPAQGFTIYADDQLLTALP
WNEVVVAYKNGAPVRIRDIGRAVDGPENARLASWQDGKRGIQLIVFKQPGANVIDAVDRV
KAAIPRLEASLPPGITVKIIGDRTETIRASVDDVQLTMLITIALVVAVIFAFLRSLWATI
IPSVTVPMALIGTFAVMYVVGYSLDNLSLMALTIAVGFVVDDAIVMLENIYRYIEEGMPP
FEAALKGAGEIGFTIISISLSLVAVFIPVLLMGGIVGRLLHEFAVTVTITILVSVVVSLT
LTPMMCSLFLKNEHNVKHGRAYMAAEAFFDGMLKVYDTGLKWVLSHQFLTLMSLLATVAA
TGWLYVAIPKGFFPQQDTGFIQGFSEAAQDISFSAMTSKQMALLDIVARDPAIEHVSGSV
GATGGSQTINTGRVWITLKPRNERDVTADEVIHRLRPQLAKVEGIALFLQASQDINVGGR
ASRTQYQYTLQDANLDELNAWGPRMLAKLKSLPELTDVATDQQTNAPTVSLTIDRDTAAR
FGILPQVIDDTLYDAFGQRQVAQYFTQLSQYHVILEVDPKLQTDPGALDKVYVRSPRTGE
EIPLSAFVKVDNSKTAYLSISHQGQFPAVTLSFNLAPGVALGQAVDAIKQAEQEAGMPQT
LIGTFQGTAQAFQNSLRTQPYLILAAIVAVYIILGVLYESFIHPLTILSSLPSAGVGALL
VLYVAGYDLSVIALIGILLLIGIVKKNAIMMIDFALVREREGKSPEDSIYEACLIRFRPI
MMTTMAALLGALPLMLGSGTGSELRRPLGFAIVGGLMVSQVLTLYTTPVVYLYMVRLQRW
LTRKRDKPAAPVRLAPVPHLDEAAE