Protein Info for GFF1403 in Variovorax sp. SCN45

Annotation: MATE efflux family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 472 transmembrane" amino acids 29 to 47 (19 residues), see Phobius details amino acids 54 to 75 (22 residues), see Phobius details amino acids 78 to 99 (22 residues), see Phobius details amino acids 111 to 134 (24 residues), see Phobius details amino acids 154 to 175 (22 residues), see Phobius details amino acids 185 to 204 (20 residues), see Phobius details amino acids 213 to 234 (22 residues), see Phobius details amino acids 262 to 287 (26 residues), see Phobius details amino acids 307 to 330 (24 residues), see Phobius details amino acids 342 to 362 (21 residues), see Phobius details amino acids 381 to 402 (22 residues), see Phobius details amino acids 409 to 429 (21 residues), see Phobius details amino acids 441 to 461 (21 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 40 to 441 (402 residues), 238 bits, see alignment E=8.6e-75 PF01554: MatE" amino acids 40 to 199 (160 residues), 108 bits, see alignment E=2e-35 amino acids 269 to 429 (161 residues), 93 bits, see alignment E=8.6e-31

Best Hits

Swiss-Prot: 48% identical to YOEA_BACSU: Probable multidrug resistance protein YoeA (yoeA) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 92% identity to vpe:Varpa_3123)

Predicted SEED Role

No annotation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (472 amino acids)

>GFF1403 MATE efflux family protein (Variovorax sp. SCN45)
MRAPPEAPGTTGPSGMKGVPVAPVGAARPLWKVFLLFLAPMLLSNILQSLSGTLNNIYVG
QMLGVGALAAVSSFFPVMFFFIAFIIGLGAGASVLIGQAWGARDAAKAKAVAGTTLTVGV
LTGLVIAVFGGAFTTPMLASLGTPPDVLADSTRYARIMLIAMPGLFVFLLATAMLRGVGD
TVTPLLTLMISTLIGLVVTPALIRGWGGLPQLGVASGAWASVLSFTVATIWLGFRLRQRK
SPLAPDAEFMRNLRIQPQLLKAVLKIGVPTGVQMIVVALAEVVLLSMVNSYGSSATAAYG
AVNQVVAYVQFPAISIAITASILGAQAIGAGRANRLGAIAKTALLMNVVLTGGLVVLGYL
FSRHLMAFFITSEPVLEIAQTLLHIMLWSLVIFGMASALSGIMRASGSVLVPTLISIVCI
LGVEVPVAYAMSHRLGLDGIWIAYPVTFGAMLLLQTAYYQLVWRKKAIHRLV