Protein Info for GFF1352 in Sphingobium sp. HT1-2

Annotation: DNA mismatch repair protein MutL

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 604 TIGR00585: DNA mismatch repair protein MutL" amino acids 1 to 304 (304 residues), 295.4 bits, see alignment E=3.5e-92 PF02518: HATPase_c" amino acids 22 to 77 (56 residues), 29.6 bits, see alignment 1.6e-10 PF13589: HATPase_c_3" amino acids 24 to 124 (101 residues), 39.3 bits, see alignment E=1.3e-13 PF01119: DNA_mis_repair" amino acids 207 to 323 (117 residues), 117.7 bits, see alignment E=4.7e-38 PF08676: MutL_C" amino acids 420 to 560 (141 residues), 161 bits, see alignment E=3.1e-51

Best Hits

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (604 amino acids)

>GFF1352 DNA mismatch repair protein MutL (Sphingobium sp. HT1-2)
MSIRRLPEHLVNRIAAGEVVERPASALKEIVENALDAGATRIAVRLSSGGLDRIEVSDDG
CGMDSQDMALALERHATSKMPDDAIENVATLGFRGEALPSIASVARLSIDSRPRGADGWN
RTVDNGVLVAEGPAALPPGTRVTVDQLFARVPARRKFLRSAKSEYAACLDVMRRLAMAHP
SVAFSVEHDGRRVLGVQAGEAREERVAALTDRQLADNHVIVSLERDGVQLSGVASLPTYN
RGVGDHQYLFVNGRPVRDRLLIGALRGAYADMLARDRHPVVALFLDVPPLEVDVNVHPAK
TEVRFRDPALIRGMIVSGLRRALDAEGFRAVQHADPAALNAWRPEPLSPTPIGAMPIFEA
AATPYAPPSYSQFAPSSPAGYQGVGDRRPSFLTPPPQARAEPAAAPAPEGHSFPLGVARG
QVARTYIVAEAEDGLVIVDQHAAHERLTLERMRRAMEGQGVASQALLLPEVVELDEPACD
RLEARVAELKEFGLELERFGPSAMLVRATPAMLGQGDVQGLVSDLADDLAAYDSALSLKE
RLDLVAATMACHGSVRAGRILSVAEMNALLREMEVTPRSGQCNHGRPTWVKLDLSAVAKL
FGRH