Protein Info for GFF1316 in Variovorax sp. SCN45

Annotation: Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 720 transmembrane" amino acids 21 to 40 (20 residues), see Phobius details amino acids 46 to 63 (18 residues), see Phobius details amino acids 70 to 89 (20 residues), see Phobius details amino acids 103 to 125 (23 residues), see Phobius details amino acids 395 to 413 (19 residues), see Phobius details amino acids 419 to 444 (26 residues), see Phobius details amino acids 465 to 475 (11 residues), see Phobius details amino acids 508 to 530 (23 residues), see Phobius details amino acids 540 to 563 (24 residues), see Phobius details TIGR03030: cellulose synthase catalytic subunit (UDP-forming)" amino acids 26 to 700 (675 residues), 892.8 bits, see alignment E=7e-273 PF13641: Glyco_tranf_2_3" amino acids 147 to 373 (227 residues), 61.1 bits, see alignment E=5.1e-20 PF00535: Glycos_transf_2" amino acids 150 to 319 (170 residues), 78.4 bits, see alignment E=1.9e-25 PF13506: Glyco_transf_21" amino acids 212 to 372 (161 residues), 27.9 bits, see alignment E=4.7e-10 PF13632: Glyco_trans_2_3" amino acids 229 to 423 (195 residues), 72.5 bits, see alignment E=1.3e-23 PF03552: Cellulose_synt" amino acids 318 to 437 (120 residues), 40.5 bits, see alignment E=4.4e-14 PF07238: PilZ" amino acids 567 to 662 (96 residues), 53.9 bits, see alignment E=6e-18

Best Hits

Swiss-Prot: 61% identical to BCSA_XANAC: Cellulose synthase catalytic subunit [UDP-forming] (bcsA) from Xanthomonas axonopodis pv. citri (strain 306)

KEGG orthology group: K00694, cellulose synthase (UDP-forming) [EC: 2.4.1.12] (inferred from 88% identity to vpe:Varpa_3208)

Predicted SEED Role

"Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12)" (EC 2.4.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.4.1.12

Use Curated BLAST to search for 2.4.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (720 amino acids)

>GFF1316 Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12) (Variovorax sp. SCN45)
MNSAPPSAPPPPRPAPALLRLLPVRIIGWLVALAILPALIITPMTFQQQIVLSVGIFVAA
LITNRIKGRFASLVLIFMSVIVSSRYTYWRVTETMFMDNPVDLVLGIGLLMAELYAFVVL
LLGYVQTAWPLERKPVPLPEDPAEWPTIDLFIPTYNEALSVVRSTVLAAQSIDWPRDKIK
IFVLDDGRREEFRVFCEDVGVTHVTRDNNRHAKAGNINAALKNTTGEFVAIFDCDHIPTR
SFMQIAMGWFGRDPKLGMVQLPHYFFSADPFERNLDTFGTVPNEGELFYGLIQDGNDLWN
ATFFCGSCAVLRRTIVEEVGGIAVETVTEDAHTALKMHRRGYSTAYLALPQAAGLATESL
SGHVGQRIRWARGMAQIFRIDNPLFGRGLHWAQRLCYVNAMLHFLYGLPRLIYLTAPLAY
LYFGASVIHASASMIFAFALPHILHANLTNSRIQGRFRYLLWNEVYEAVLAWYIFRPTLV
ALINPKLGSFNVTAKGGLIQQEYFDTTIAKASLVLLALNFVGVCLGAWRLTWVDPQNIAT
VWLNLAWTVYNLMILGACVAAANESRQLRGAHRVELNLPATLYFADGRSLRCNTFDFSSG
GLGVELPSDLKLDLETPVEVALYRNDQESRFASTVRFSSGRRVGLRFAPMSFAQERALVQ
CTTARADIWAARWGNHPRVPIYRVLGHLISISGTGFRDMFSHYYRATVSRLRPAKAKEST