Protein Info for GFF1266 in Xanthobacter sp. DMC5

Annotation: Cytochrome c oxidase subunit 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 541 transmembrane" amino acids 38 to 59 (22 residues), see Phobius details amino acids 81 to 102 (22 residues), see Phobius details amino acids 123 to 141 (19 residues), see Phobius details amino acids 173 to 197 (25 residues), see Phobius details amino acids 212 to 238 (27 residues), see Phobius details amino acids 262 to 282 (21 residues), see Phobius details amino acids 294 to 317 (24 residues), see Phobius details amino acids 331 to 353 (23 residues), see Phobius details amino acids 365 to 386 (22 residues), see Phobius details amino acids 402 to 423 (22 residues), see Phobius details amino acids 436 to 457 (22 residues), see Phobius details amino acids 480 to 504 (25 residues), see Phobius details TIGR02891: cytochrome c oxidase, subunit I" amino acids 28 to 539 (512 residues), 725.6 bits, see alignment E=1.5e-222 PF00115: COX1" amino acids 36 to 487 (452 residues), 540.9 bits, see alignment E=1.2e-166

Best Hits

Swiss-Prot: 79% identical to COX1_BRADU: Cytochrome c oxidase subunit 1 (ctaD) from Bradyrhizobium diazoefficiens (strain JCM 10833 / IAM 13628 / NBRC 14792 / USDA 110)

KEGG orthology group: K02274, cytochrome c oxidase subunit I [EC: 1.9.3.1] (inferred from 95% identity to xau:Xaut_4647)

MetaCyc: 68% identical to complex IV subunit 1 (Arabidopsis thaliana col)
CYTOCHROME-C-OXIDASE-RXN [EC: 7.1.1.9]

Predicted SEED Role

"Cytochrome c oxidase polypeptide I (EC 1.9.3.1)" in subsystem Terminal cytochrome C oxidases (EC 1.9.3.1)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.9.3.1

Use Curated BLAST to search for 1.9.3.1 or 7.1.1.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (541 amino acids)

>GFF1266 Cytochrome c oxidase subunit 1 (Xanthobacter sp. DMC5)
MATEAVTHSHHDDHDTHDSHIPTGWKRWVFSTNHKDIGVMYLIFAIVAGIVGGALSIAIR
MELQEPGLQIFKDPQTFNVFTTGHGLIMIFFMVMPALIGGYGNYFAPLMIGAPDTAFPRI
NNIAFWLLPPAFILALSSLFVEGAPGTNGFGGGWTIYPPLSSKLGHPGPAMDLLIFSLHI
AGASSLLGAINLITTIFNMRAPGMTLHKMPLFAWSQLITGFLLLLSLPVLAGAITMLLTD
RNFGTTFFDPAGGGDPILFQHLFWFFGHPEVYILILPGFGLISHIISTFSRKPVFGYLGM
AYAMVAIGVVGFVVWAHHMYTVGLSSGTQSYFVAATMIIAVPTGVKIFSWIATMWGGSIQ
FRTPMLWAIGFIFLFTVGGVTGVVLSNAGIDRSLHDTYYVVAHFHYVLSLGAVFAIFAGW
YYWFPKMFGYMIPEFWGKLHFWVTFIGVNLVFFPQHFLGLAGMPRRYADYPDAFAHWNFV
SSIGSYISGIAVLIFLTGTTLAFLRKEKAADNPWGEGATTLEWTLSSPPPYHQFEVLPRI
K