Protein Info for PS417_06190 in Pseudomonas simiae WCS417

Annotation: sodium:proton antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 547 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 38 to 63 (26 residues), see Phobius details amino acids 82 to 104 (23 residues), see Phobius details amino acids 111 to 133 (23 residues), see Phobius details amino acids 154 to 174 (21 residues), see Phobius details amino acids 180 to 200 (21 residues), see Phobius details amino acids 214 to 231 (18 residues), see Phobius details amino acids 237 to 256 (20 residues), see Phobius details amino acids 268 to 287 (20 residues), see Phobius details amino acids 307 to 333 (27 residues), see Phobius details amino acids 356 to 380 (25 residues), see Phobius details amino acids 393 to 416 (24 residues), see Phobius details TIGR00831: Na+/H+ antiporter" amino acids 8 to 543 (536 residues), 437 bits, see alignment E=4.5e-135 PF00999: Na_H_Exchanger" amino acids 13 to 417 (405 residues), 231.7 bits, see alignment E=6.7e-73

Best Hits

KEGG orthology group: K03316, monovalent cation:H+ antiporter, CPA1 family (inferred from 98% identity to pfs:PFLU1266)

Predicted SEED Role

"Na+/H+ antiporter" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UBB3 at UniProt or InterPro

Protein Sequence (547 amino acids)

>PS417_06190 sodium:proton antiporter (Pseudomonas simiae WCS417)
MQTAYTVLILLMLVSVSRLVGRVIPLPLPLVQIAAGALLAWPTLGLHVALDPELFLFLFL
PPLLFSDGWRMPKRELWRLRGPILTLAVGLVLFTVVGAGYFIHWLLPTIPLPVAFALAAV
LSPTDAVAVSAISQNRLPTPLMHMLQGEALMNDASGLVTFKFALAAALTGVFSLADASLT
FVLVAVGGLAVGVALSWLVGRLRAWMIARGWDDPATHVVFMLLLPFAAYVLAERLGASGI
LSAVAAGMMQSWLDLLPRQTSTRLLNRSVWSLLEFAFNGLIFLLLGLQLPDIIKAVVSHE
PTLWPTLFYRCLDVVAIFLVLVVLRFIWVQSIWRLSGLLRRLRGKSELTLVPTARSCWLL
TVGGVRGAVTLAGVMSVPLLLAPGQDFPERDLLIFIAAGVILLSLIAACITLPLLLRGIE
KSPDEKRHEEVREAWKKTAVAAIHALEAEEPAEVETQDAAQAALATELKARLMSEYRHQL
EVFNDSAEAQALAQQMDLLERKLRLKALRAQRLELYSLSRHHQIGDDVLREVLAELDMSE
ANLGQVK