Protein Info for GFF1218 in Sphingobium sp. HT1-2

Annotation: Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 1458 transmembrane" amino acids 7 to 26 (20 residues), see Phobius details amino acids 32 to 49 (18 residues), see Phobius details amino acids 55 to 72 (18 residues), see Phobius details amino acids 88 to 109 (22 residues), see Phobius details amino acids 386 to 399 (14 residues), see Phobius details amino acids 401 to 425 (25 residues), see Phobius details amino acids 495 to 516 (22 residues), see Phobius details amino acids 528 to 549 (22 residues), see Phobius details amino acids 712 to 734 (23 residues), see Phobius details amino acids 1423 to 1444 (22 residues), see Phobius details TIGR03030: cellulose synthase catalytic subunit (UDP-forming)" amino acids 11 to 687 (677 residues), 874.8 bits, see alignment E=2e-267 PF13641: Glyco_tranf_2_3" amino acids 130 to 357 (228 residues), 61.2 bits, see alignment E=4.4e-20 PF00535: Glycos_transf_2" amino acids 134 to 301 (168 residues), 79 bits, see alignment E=1.5e-25 PF13632: Glyco_trans_2_3" amino acids 213 to 411 (199 residues), 68.7 bits, see alignment E=2.3e-22 PF03552: Cellulose_synt" amino acids 297 to 428 (132 residues), 29.9 bits, see alignment E=7.8e-11 PF07238: PilZ" amino acids 554 to 650 (97 residues), 46.8 bits, see alignment 1.1e-15 PF03170: BcsB" amino acids 754 to 1358 (605 residues), 671.2 bits, see alignment E=4.6e-205

Best Hits

KEGG orthology group: K00694, cellulose synthase (UDP-forming) [EC: 2.4.1.12] (inferred from 66% identity to npp:PP1Y_Lpl1114)

Predicted SEED Role

"Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12)" (EC 2.4.1.12)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.1.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1458 amino acids)

>GFF1218 Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12) (Sphingobium sp. HT1-2)
VKGRQAILSNGLLVLAGLFALLAITVPLDLEAQWIFAGITIVGATILGRLRSRRALLVLA
ILSMIVSTRYMFWRTTETLEFGTLAEFLLGSGLYLAEVYAWLILVLGFLQTGWPLDREVV
EIEGEPDQWPSVDVYVPTYNESLEIVRNTVFAAMDMDYPADRFRVFILDDGRRPEFQAFA
RQAGCGYLTRGDNLHAKAGNLNAAMKKTNGELIAIFDCDHVPTRAFLQMTVGWFQQDPKL
ALMQTPHHFYSPDPAQRNLGTVRDLPGEGDLFYGAVQSGNDLWNATFFCGSCAIIRRDAL
AQTNGFAGETVTEDAHTALKLQRMGWNTAYIGARLSAGLATERLVLHIGQRIRWARGMTQ
ILRIDNPLFGRGLNWQQRLCYLNAMLHFQFPLPRIVFLTSPLAYLIFGQNIIHASASLIF
AYALPHLVCSMTSSANTQGGDRRPFWGEIYETILAFHLARPTVMTFFQPRKGKFNVTDKG
SLLDRTYFDLSTVRPHLICIGLIIFGIGLAIVKRVFFPHLFNIQTDTLVLNVVWAVFSLI
ILIAAVSVARETRQAREYIRIVTELPVTLYMADGYVIDATTIDISMGGAAIAVPPDFPLR
DRRVGHMSLPMGDEKLTIPVEMVRFDRGEVNLRFQELDMISSRHLVRAVMGRADAWQPAA
PRKPVSALHSLWDIIVVDYMTLKRLFRLNRTERRKQKKAVRLAAAAKAAKQAAAALLGLA
AIGTLVLAGSGHAFAQAAQAPAATLAPATAAGVQKQRLSFRDLQVKMPIRLAGTRGEIGI
PFGMRRNEVVTDSSLTLNFAWSPAMLGDLSQLVVLLNGEVVRTIRLTPAESGGQNITIPV
NPALFLPGDNQLNLRLVGHYARDCEDPFHSSLWANISNVRSWFDLSVQTLPMAPDLGRLP
GPFFDRHDNLPLRLPFVFAGTPRAGELEAAASLASWLGAQASYRGFSFKPVYNQIPTGNA
ILFATPDRPIAGLNLSITGPSATVIRNPRDTFGELLVVMGRNASELKLAAAAIASGRGVL
SGARMNFDGVRIPTYARYAAPRWLRTDRPVQLGEIMDANALQGMGLPPGPLSARFRVAPD
LFFWPRQGGRLDLRYRYPAAKWLDRRASRLDVSINNQYLRTLPLAGAGWWDSLFGAQGAS
SNDSSASIVLPRYNLFGQNELIFDYNLIIADKKKCEGTLPENVRVSVRPSSSIDLSRAYH
ALHMPDLATFAGAGYPFTIRPDLSETTVLMGGQPSAGAVEAFLVLMGRMGDSTGAPVTGV
VVANAVDGERLQGRDIIVIGGSSVAGSDQLFAGAPVRYENGRLQVTEMSPIQRIFAFFSP
FDRSGDGEADAFVTSSSGFAGIVGFESPFEGGRSVVALLADDPRALPDLVGGMADAKINA
QIQGDLAVTSGDGMSSFAVGPGYWVGYLPFWMKAAFWLSQRPLLMAACGLLAALILAGPL
YLYLSRQQRRRLSKEDEA