Protein Info for GFF1205 in Hydrogenophaga sp. GW460-11-11-14-LB1

Annotation: Benzaldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 525 PF00171: Aldedh" amino acids 19 to 453 (435 residues), 201.7 bits, see alignment E=9e-64

Best Hits

Swiss-Prot: 56% identical to BOXD_AZOEV: 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase (boxD) from Azoarcus evansii

KEGG orthology group: K02618, phenylacetic acid degradation protein (inferred from 73% identity to lch:Lcho_3656)

MetaCyc: 56% identical to 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase monomer (Aromatoleum evansii)
RXN-11053 [EC: 1.2.1.77]

Predicted SEED Role

"Benzaldehyde dehydrogenase"

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.77

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (525 amino acids)

>GFF1205 Benzaldehyde dehydrogenase (Hydrogenophaga sp. GW460-11-11-14-LB1)
MTTSSLLPNFLGGQWQTGTGAGTPLFDPVLGTELARVSSAGLDLAAGFRFAREQGGRALR
ALSYGERAGLLAAIVKVLQANRDAYYEIATANSGTTTKDSAVDIDGGIFTLGYYAKQGEA
LGSARALLDGERIRMGKDPVFQTQHVLQPTHGVALFINAFNFPSWGLWEKAAPALLSGVP
VIIKPATATAWLTQRMVKDVIDANILPVGALSVVCGSSAGLMDQLQPFDVVSFTGSADTA
RIIRSHPAVAERSVRCNIEADSLNSALLDPAATADSDAFNLLVSEVVREMTVKSGQKCTA
IRRVFVPRALFDAAAQAIGAKLTKTSVGNPRNESVRMGSLVSQEQKASVLEGIARLRSEA
EVLFDGSGAALVDADAAVAACVAPTLLGSREPAKAKVLHEVEVFGPVATLMAYDGIEQAY
ELIRRGEGSLVCSVYSADPAFTASAALELGSAHGRVHAISPDVAASQTGHGNVMPMSLHG
GPGRAGGGEELGGLRALGFYHRRSAVQASSAALDALAASAVALKY