Protein Info for PS417_06115 in Pseudomonas simiae WCS417

Annotation: multidrug transporter AcrB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1021 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details transmembrane" amino acids 336 to 355 (20 residues), see Phobius details amino acids 362 to 382 (21 residues), see Phobius details amino acids 388 to 412 (25 residues), see Phobius details amino acids 427 to 451 (25 residues), see Phobius details amino acids 464 to 486 (23 residues), see Phobius details amino acids 531 to 550 (20 residues), see Phobius details amino acids 865 to 882 (18 residues), see Phobius details amino acids 889 to 909 (21 residues), see Phobius details amino acids 915 to 936 (22 residues), see Phobius details amino acids 963 to 983 (21 residues), see Phobius details amino acids 989 to 1013 (25 residues), see Phobius details PF00873: ACR_tran" amino acids 6 to 1011 (1006 residues), 565.9 bits, see alignment E=1.6e-173 PF03176: MMPL" amino acids 847 to 1012 (166 residues), 28.1 bits, see alignment E=1e-10

Best Hits

KEGG orthology group: None (inferred from 88% identity to pen:PSEEN4240)

Predicted SEED Role

"RND efflux transporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7UDW4 at UniProt or InterPro

Protein Sequence (1021 amino acids)

>PS417_06115 multidrug transporter AcrB (Pseudomonas simiae WCS417)
MGFNLSEWALRNRQIVLFLMILLAVVGTLSYSKLGQSEDPPFTFKAMVIKTNWPGATAQE
VSRQVTERIEKKLMETGEYERIVSFSRPGESQVTFIARDSMHSAQIPELWYQVRKKISDI
RQTLPPDIQGPFFNDEFGTTFGNIYALTGDGFDYAVLKDYADRIQIQLQRVADVGKVELL
GLQDEKIWIELSNLKLATLGLPLAAVQQALQEQNAVSTAGFFETPSERVQLRVSGNFKTV
EEIRNFPIRVGDRTFRIGDVADIHRGFNDPPAPRMRYMGADAIGLAVAMRDGGDILVLGK
ALEGEFARLQKNLPAGMELRKVSDQPAAVKTSVGEFVQVLAEALAIVLLVSFFSLGVRTG
MVVALAIPLVLAMTFATMYYLGIGLHKISLGALVLALGLLVDDAIIAVEMMAIKMEQGYD
RLKAASFAWTSTAFPMLTGTLITAAGFLPIATAQSSTGEYTRSIFQVVTIALLASWVAAV
VFVPYLGEKLLPDLAKIHAAKHGTDGPDPYGTPFYQRVRRMVEWCVRRRKTVIVLTLLLF
IGSVALFRFVPQQFFPASGRLELMVDLKLAEGASLSNTADQVKRLEALLKEHAGIDNYVA
YVGTGSPRFYLPLDQQLPAASFAQFVVLAKTIEERESLRTWLIQTLNEQFPDLRSRVTRL
ENGPPVGYPVQFRVTGEHIEEVRALARKVAVKVRENPHVANVHLDWEEPSKIVYLNIDQD
RARALGVSTANLSKFLQSSLTGSSVSQYREDNELIEILLRGTVHERTELSLLPSLAVPTD
NGKSVALSQIATLEYGFEEGIIWHRNRLPTVTIRADIYGKEQPATLVQQILPTLEGVRAE
LPDGYLLDVGGTVEDSARGQNSVKAGVPLFIVVVLTLLMLQLRSFSRTAMVFLTAPLGLI
GVTLFLLVFRQPFGFVAMLGTIALSGMIMRNSVILVDQIEQDIKAGLAPWQAIIEATVRR
FRPIVLTALAAVLAMIPLSRSVFFGPMAVAIMGGLIVATALTLLFLPALYAAWFRVKPQA
G