Protein Info for GFF1034 in Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868

Annotation: '5'-nucleotidase YjjG (EC 3.1.3.5)' transl_table=11

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR02254: noncanonical pyrimidine nucleotidase, YjjG family
  • amino acids 4 to 221 (218 residues), 242.9 bits, E=4.2e-76
• PF00702: Hydrolase
  • amino acids 4 to 189 (186 residues), 93.4 bits, E=3.7e-30
• PF13419: HAD_2
  • amino acids 79 to 194 (116 residues), 70.6 bits, E=2.9e-23
• TIGR01509: HAD hydrolase, family IA, variant 3
  • amino acids 92 to 195 (104 residues), 40 bits, E=6.7e-14
• TIGR01549: HAD hydrolase, family IA, variant 1
  • amino acids 101 to 189 (89 residues), 58.9 bits, E=1.2e-19
• PF13242: Hydrolase_like
  • amino acids 149 to 218 (70 residues), 45 bits, E=1.2e-15

Best Hits

Swiss-Prot: 91% identical to YJJG_ECO57: Pyrimidine 5'-nucleotidase YjjG (yjjG) from Escherichia coli O157:H7

KEGG orthology group: K08723, 5'-nucleotidase [EC: 3.1.3.5] (inferred from 99% identity to sty:STY4909)

MetaCyc: 91% identical to pyrimidine 5'-nucleotidase YjjG (Escherichia coli K-12 substr. MG1655)
3.1.3.M8 [EC: 3.1.3.M8]; 5'-nucleotidase. [EC: 3.1.3.M8, 3.1.3.5]

Predicted SEED Role

"5'-nucleotidase YjjG (EC 3.1.3.5)" (EC 3.1.3.5)

MetaCyc Pathways

• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• NAD salvage pathway III (to nicotinamide riboside) (2/3 steps found)
• adenosine nucleotides degradation II (3/5 steps found)
• adenosine nucleotides degradation I (5/8 steps found)
• guanosine nucleotides degradation I (2/4 steps found)
• guanosine nucleotides degradation II (2/4 steps found)
• guanosine nucleotides degradation III (2/4 steps found)
• ureide biosynthesis (4/7 steps found)
• superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
• purine nucleotides degradation I (plants) (7/12 steps found)
• NAD salvage (plants) (5/11 steps found)
• superpathway of purines degradation in plants (10/18 steps found)
• tunicamycin biosynthesis (2/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Nicotinate and nicotinamide metabolism
• Purine metabolism
• Pyrimidine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.1.3.5

Use Curated BLAST to search for 3.1.3.5 or 3.1.3.M8

Protein Sequence (225 amino acids)

>GFF1034 '5'-nucleotidase YjjG (EC 3.1.3.5)' transl_table=11 (Salmonella enterica subsp. enterica serovar Typhimurium str. MS1868)
MKWDWIFFDADETLFTFDSFTGLQRMFLDYSVTFTAEDFQDYQAVNKPLWVDYQNGAITS
LQLQHARFQSWAERLNVAPGLLNDAFISAMAEICSPLPGAVSLLNAIRGQAKIGIITNGF
TALQQTRLERTGLREYFDLLVISEQVGVAKPDPKIFNYALEQAGNPDRSRVLMVGDTAES
DILGGINAGLSTCWLNAHHREQPAGIHPTWTVASLSELEQLLCKH