Protein Info for GFF103 in Variovorax sp. SCN45

Annotation: General secretion pathway protein E

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 TIGR02533: type II secretion system protein E" amino acids 2 to 447 (446 residues), 669.4 bits, see alignment E=1.4e-205 PF00437: T2SSE" amino acids 75 to 445 (371 residues), 484.3 bits, see alignment E=9.5e-150

Best Hits

Swiss-Prot: 73% identical to HXCR_PSEAE: Probable type II secretion system protein HxcR (hxcR) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K02454, general secretion pathway protein E (inferred from 76% identity to sml:Smlt2741)

Predicted SEED Role

"General secretion pathway protein E"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (450 amino acids)

>GFF103 General secretion pathway protein E (Variovorax sp. SCN45)
MVVCERTPGWAVVEARLLLGELPLKQIASPEMDALLGATYAETGDAASVVGAVEQQVDLD
RLMQDIPAVTDLLDAQDDAPVIRMINALLAQAARDGASDIHLESFETHSVVRYRVDGTLR
DVVAPRKALHAALISRIKIMSQLDIAEKRLPQDGRITLRVGGRPIDVRVSTVPTAHGERA
VLRLLEKDAGRLRLERLGMAPDTLAELTRLVRQPHGIVLVTGPTGSGKTTTLYAALGQLD
LSTSNILTVEDPVEYDLPGIGQIPVHGKIGMTFGAALRAALRQDPDNIMIGEIRDLETAQ
IAVQSSLTGHGVLASLHTNDAVSAVTRMTDMGIEPFLLSSSLLGVLAQRLVRCLCPACKA
PQTRPDGSVVYGPVGCAACGHSGFKGRTGIHELFVVHDDVRRLIHEGGDEQAMRAAAAKR
GMRSMREDGQRWVREGITTAEEILRVTRDA