Protein Info for PS417_05080 in Pseudomonas simiae WCS417

Annotation: LysR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 315 PF00126: HTH_1" amino acids 12 to 69 (58 residues), 76 bits, see alignment E=1.8e-25 PF03466: LysR_substrate" amino acids 94 to 301 (208 residues), 113.7 bits, see alignment E=7.9e-37

Best Hits

Swiss-Prot: 34% identical to AMPR_PSEAE: HTH-type transcriptional activator AmpR (ampR) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: K03566, LysR family transcriptional regulator, glycine cleavage system transcriptional activator (inferred from 99% identity to pfs:PFLU1036)

Predicted SEED Role

"Glycine cleavage system transcriptional activator" in subsystem Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A1N7U031 at UniProt or InterPro

Protein Sequence (315 amino acids)

>PS417_05080 LysR family transcriptional regulator (Pseudomonas simiae WCS417)
MTRPLHGQTYVWLHVFSCAARHLSFTRCAEELHITPGAVSQQIRQLEERLGFRLFHRRAR
GVELSAEGQRLAATVGEAYGSIDAELQRLDAGMISGTLRLRSIPSFLGKWLTPRLPRLQQ
RFPDIQLRMVAEDSSIALHEGDFDLAIDLNDGSYPGLLSTALLDEQIFPVCAPSLLRGRP
PLHGPADLVHFPLLHDITAWRGSYEYAEWEFYLNAIGYHHADVRRGHTFNRNHLTIEAAI
AGMGVAIARRTLLNDELERGTLIVPFGLAVPNYKRYVLLYAPGALSHPGVRAVHDWLVEE
AGIFRGLHPLGEGQL