Protein Info for Echvi_4670 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: ATP-dependent protease La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 827 PF02190: LON_substr_bdg" amino acids 45 to 235 (191 residues), 164.8 bits, see alignment E=6.7e-52 TIGR00763: endopeptidase La" amino acids 46 to 805 (760 residues), 946.9 bits, see alignment E=5.6e-289 PF00004: AAA" amino acids 386 to 524 (139 residues), 90.1 bits, see alignment E=4.3e-29 PF07728: AAA_5" amino acids 386 to 520 (135 residues), 39.6 bits, see alignment E=1.3e-13 PF05362: Lon_C" amino acids 603 to 806 (204 residues), 282.6 bits, see alignment E=4.4e-88 PF13541: ChlI" amino acids 647 to 774 (128 residues), 31.5 bits, see alignment E=3.5e-11

Best Hits

Swiss-Prot: 68% identical to LON_CYTH3: Lon protease (lon) from Cytophaga hutchinsonii (strain ATCC 33406 / NCIMB 9469)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 73% identity to mtt:Ftrac_0807)

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G5L2 at UniProt or InterPro

Protein Sequence (827 amino acids)

>Echvi_4670 ATP-dependent protease La (Echinicola vietnamensis KMM 6221, DSM 17526)
MKKNDSSLYQSLIVGDFAGEGDLIQLITDDEEDEQARLENYAEDIPILSVRNTVLFPGVV
IPITVGRQRSIKLVKKAHKGDKMIGVCAQINPNNDDPGWDDIYHVGTIAKIIKMIVLPDG
NTTIIIQGKKRFKIRETITEEPYFQAKVDYLDETFPEGNKQITALEESLKEAAAKILQLN
PEIPREAQVALDNIDNTAFLTHFLSSNINAPVEAKQKLLEINDGLDRATLLLEYMMKDIQ
MLELKSEIHKKVHTDIDQQQRDYFLRQQMKVLQTELGEEGPEKEVEELRLKGRKKKWPEE
VGKHFEKELDKILRVNPSAAEYPIALNYAELMVDLPWNEFTKDNFDLKRAKEILDKDHHG
LEKVKDRIIEYLAVLKLKNDLKGPILCLYGPPGVGKTSLGKSIAKALGRKYIRMSLGGMH
DEAEIRGHRKTYVGAMPGKIIQNMKKVQTSNPVYVLDEIDKLSADFRGDPSSAFLEVLDP
EQNSSFVDNYLEVEYDLSKVLFIATANSLESIQPALRDRMEIIEVTGYTMEEKVEIAKKH
LIPKQRKEHGLKAKDISFDKAAIVKIIEGYTRESGVRSLERQVGTVIRNVAKSIAMEEDY
QKKITPEMVRKILGGEMFDKEIYQDNSVAGVVTGLAWTSVGGEILFVESSLSKGKGKLTL
SGQLGDVMKESAMTAMSYLRSKADQLNIDSRVFDQYDLHVHVPAGAVPKDGPSAGITMLT
ALASLYTQRKVKAKLAMTGEITLRGKVMPVGGIKEKILAAKRAGIKDIILCKRNQKDIEE
IHERYVKGVNFHFVDNVNEVLELALLNQKVDHPMKFTFEDNQKSVQA