Protein Info for Echvi_4428 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1228 PF18076: FGAR-AT_N" amino acids 12 to 81 (70 residues), 35.5 bits, see alignment 2.3e-12 PF18072: FGAR-AT_linker" amino acids 122 to 171 (50 residues), 67.1 bits, see alignment (E = 3.9e-22) PF02769: AIRS_C" amino acids 381 to 533 (153 residues), 85.5 bits, see alignment E=1.1e-27 amino acids 780 to 909 (130 residues), 55.9 bits, see alignment E=1.5e-18 PF22689: FGAR-AT_PurM_N-like" amino acids 595 to 748 (154 residues), 155.9 bits, see alignment E=2e-49 PF13507: GATase_5" amino acids 981 to 1224 (244 residues), 282.4 bits, see alignment E=6.8e-88

Best Hits

KEGG orthology group: K01952, phosphoribosylformylglycinamidine synthase [EC: 6.3.5.3] (inferred from 63% identity to bfs:BF3154)

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G500 at UniProt or InterPro

Protein Sequence (1228 amino acids)

>Echvi_4428 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain (Echinicola vietnamensis KMM 6221, DSM 17526)
MILFFQSPQKNTIYALEAKQPVAPEDLQKLSWLFGEADQLAQEKVEGSFAGPRKEMITPW
STNAVEIAANMGIPEILRIEEFSLLEEGQKIDPMLQAKYPGLDQDIFTIDLKPEEVLPIT
DIKSYNAQEGLALSDEEIEYLEKVSKSLSRPLTDSEVFGFSQVNSEHCRHKIFNGTFIID
GEEKENTLFQLIKKTSIKHPNKIVSAYKDNVAFVKGPKAQQFAPKSQDKADYFQPQTIDT
VLSLKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGTASVPLAGTAVYMTSYSRSEAGRS
WEKDLKERKWLYQTPMDILIKASNGASDFGNKFGQPLISGSVLTFEHEENDKQFGFDKVI
MLAGGIGFTREKYSLKNTPVKGNKIVIMGGDNYRIGMGGSAVSSVNTGEFSNSIELNAIQ
RSNPEMQKRVANVIRAMAENDHNPIISIHDHGAGGHLNCLSELVEDTGGNIDIDKLPVGD
PTLSAKEIIGNESQERMGLVIGKEHVETLKKISERERAPFYVVGETTGDMHFKFENKNSG
EKPVDWDLSHMFGSSPKTILTDKKTTVNYAEPAYKVDALEHYIAEVLQLEAVACKDWLTN
KVDRSVTGRVATQQTTGAIQVPLNNVAVMAIDFTGKKGIATSIGHAPVAALADPEAGSKL
AIAEALTNLVWAPIEDGLSGVSLSANWMWPAKNEGENDRLYRAVQAVSDFAIDLGINIPT
GKDSLSMTQKYPDGKTVYSPGTVIISSVGECADIRKTVTPDLKPAVGTEILYIDFSRDSA
QLGGSSFAQVVNKIGSTPPTVKDSTYFAKAFMAVQQLIGKGMLLSGHDISSGGLITALLE
MAFPTQECGLKINTDQLAEKDIIKALFAENPGVVIQAKEAKAVKATLDELGISYIALGEV
TADSKITLEGQGLSLDVAEHRDTWFRSSFLLDQKQSGKKLAKERFENYKHQALDFTFGKD
WEGTYDAFKLNPFRHDASGTKAAIIREKGVNGDREMAYALWLAGFDVKDVHMTDLIAGRE
TLEDVNMIVFVGGFSNSDVLGSAKGWAGAFLYNEKAKTALDKFYARPDTLSLGVCNGCQL
MIELGLINRDHDVKPKMLHNESHKFESAFVNVDIPENNTVMFGSLSGQRLGVWVAHGEGK
FSLPKDQEAYNIGMKYSYQAYPGNPNGSDHAVAGLASRDGRHLAIMPHIERSLAPWNWPH
YPSDLKDQEITPWVEAFVNAKEWVASHQ