Protein Info for Echvi_4346 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Signal transduction histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1300 1400 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 818 to 840 (23 residues), see Phobius details PF07494: Reg_prop" amino acids 39 to 62 (24 residues), 20.6 bits, see alignment (E = 1.6e-07) amino acids 84 to 107 (24 residues), 22.5 bits, see alignment (E = 3.9e-08) amino acids 187 to 209 (23 residues), 16.9 bits, see alignment (E = 2.5e-06) amino acids 236 to 253 (18 residues), 18.5 bits, see alignment (E = 7.7e-07) amino acids 275 to 297 (23 residues), 17.9 bits, see alignment (E = 1.2e-06) amino acids 323 to 345 (23 residues), 21.8 bits, see alignment (E = 6.2e-08) amino acids 421 to 441 (21 residues), 15.1 bits, see alignment (E = 9.4e-06) amino acids 466 to 487 (22 residues), 16.8 bits, see alignment (E = 2.7e-06) amino acids 517 to 538 (22 residues), 18.2 bits, see alignment (E = 9.5e-07) amino acids 564 to 586 (23 residues), 20.6 bits, see alignment (E = 1.5e-07) PF07495: Y_Y_Y" amino acids 747 to 809 (63 residues), 54.2 bits, see alignment (E = 4.9e-18) PF00512: HisKA" amino acids 865 to 930 (66 residues), 49.3 bits, see alignment 1.9e-16 PF02518: HATPase_c" amino acids 978 to 1094 (117 residues), 72.4 bits, see alignment E=1.8e-23 PF00072: Response_reg" amino acids 1153 to 1263 (111 residues), 88.2 bits, see alignment E=1.9e-28 PF12833: HTH_18" amino acids 1320 to 1396 (77 residues), 69.4 bits, see alignment 1.2e-22 PF00165: HTH_AraC" amino acids 1359 to 1394 (36 residues), 34.5 bits, see alignment (E = 7.6e-12)

Best Hits

Predicted SEED Role

"DNA-binding response regulator, AraC family"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G4T2 at UniProt or InterPro

Protein Sequence (1400 amino acids)

>Echvi_4346 Signal transduction histidine kinase (Echinicola vietnamensis KMM 6221, DSM 17526)
MLNRLYISIITLMLTCTALHGQGTGHPYYKFTHFNSQEGLPQNSILAILQDDMGYLWFGT
DDGLAKFDGYQFTVYKHQFNNPNSLNNNVIRGLAQDKNGYIWISTEGGGINIYDPTTESF
CSLRNHALIGSKKTGPLLLDQQGNIWVSTLTDGIYKVTVPHPTEDFGLDQLVGRLKVTHY
TKDNSRLADNNIWQVYEDGSQQIWIGTYDHGAQKLDPATGAFSKITLSHRGQEVKSVKCF
FEDGNGNMWIGTEHHGVFLKERDSNTYVPFKTSSSLMGENITSFLQGQQGNIWIGTLGGG
LFAYETKTSTLFHYDDNPSDSYSLNGKSVYTMLEDKNGNLWIGMYSGEGLNKINPSSQHF
EHYRPQAGDKGSLSGKMVKSILIDHQKNLWIGMFNGGLDLKMDGSDNFRPIPLGGSTEQG
STNVQVIFEDSRHQLWIGTDGSGLYLYSPSLSSIRAYHHDPHDSTSLSKDEIWAIAEDGS
GRLWIGMANGGGLNRFDPNTDHFEHFTHIPNNPRTPSFNDIRTLLVDSKNRLWIGTYGGG
LNRYDFEKGTFEYYKHDPTNPKSISHDIITSLYEDKRGGIWVGTFGGGLNRLDPATGNFD
HFREKDGLPSDVIKAVLEDNGGQLWISTVKGLSSFDPEMDTFKNYTAEDGLQSNEFNLGS
AFKAIDGKMYFGGTNGFNAFLPEQIGLPQSPQKPILTKLRVLNRLVHPGDTVEQNVLLEK
SIGYTDDLTLYDDHNSFELEFSGMEFNQQEKIGYAYMLAGFDKDWIHTDASRRYAAYSNL
LPGKYTFKVKSTSENNLQSSEERTLRISVLPPWYKSTIAYGVYGILFLLIAYFVKSIIGF
RIKMKNDLRFERLEKQKQEEINQLKLRFFTNISHELRTPLMLIKLPLEQLIGQKDLPHQI
HLQLNSIHNNASRLLKLINQLLEFRKQETGHLKLEVQENDPIYFIKGVYSSFEAMAKQRN
IDFRLILDDNLPETIWFDLDQMEKVAYNLCFNAFKFTQDGGAISLQLKNHVLAEENTEIE
GIEINVEDNGKGIPLVYQDRIFERFFQIEDSHRNITAGTGIGLSLSKNIVEFHHGKISMS
SIPGVRTVFSVFIRKGMAHFKPHEIGNITSIGKPERPTMEKELSSLDLHMLSSFNPKNTT
ISVDASLRTKKLLLVEDNVELLSLMKSALKEHFHILTACNGREGLQVATSHSPDIIISDV
MMPEMDGVELCRLLKSEIKTSHIPVLLLTARSNHDYQMEGYSSGADDYLSKPFPLDLLIA
KIRNLLHTRKKFKEAFRLKPEIMPSEISISPADTELLEKAIKVAEKHMDNPDFDITMFVQ
EMGMSRTVLFDKIKATTDHTPNEFIQTLRLKRAAQLLLQSEYKVSEISYMVGFNNPKYFS
KCFQKQFGSSPRQYSKSIFS