Protein Info for Echvi_3900 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Thiol-disulfide isomerase and thioredoxins

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 296 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details PF08534: Redoxin" amino acids 160 to 278 (119 residues), 55.8 bits, see alignment E=9.4e-19 PF00578: AhpC-TSA" amino acids 160 to 270 (111 residues), 63.6 bits, see alignment E=3.5e-21 PF13905: Thioredoxin_8" amino acids 183 to 270 (88 residues), 39.3 bits, see alignment E=1.3e-13

Best Hits

Predicted SEED Role

"Cytochrome c-type biogenesis protein ResA" in subsystem Biogenesis of c-type cytochromes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G533 at UniProt or InterPro

Protein Sequence (296 amino acids)

>Echvi_3900 Thiol-disulfide isomerase and thioredoxins (Echinicola vietnamensis KMM 6221, DSM 17526)
MMLKNNFFLMLILTFLGSCQKEQKSSYKTVEFQKGFPEILEPIEKNLPFKIQSHSILESN
NDSIDIYIGFLKQGEQSGNWIALASNKQIKQFSTVDLNPDSENIKENDIDIEFNNSINRV
SLRIKKIDTLKNSITYSWVNQSILTDSLTVLTIDKPLVKGKIFPSIELTDINGEKFDLDN
FNGQTIVVNWWAVWCAPCRKEIPGLNKLVSKYSDNDVRFVSITDDSKDKVSSFLEKNDFE
YDITFISENDRVLFGNTYPKNIIIDNNKNIVFYKEGGNENVWFEIDQHLKEINNIE