Protein Info for Echvi_3740 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1052 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 342 to 361 (20 residues), see Phobius details amino acids 368 to 390 (23 residues), see Phobius details amino acids 397 to 419 (23 residues), see Phobius details amino acids 440 to 464 (25 residues), see Phobius details amino acids 472 to 499 (28 residues), see Phobius details amino acids 541 to 559 (19 residues), see Phobius details amino acids 875 to 894 (20 residues), see Phobius details amino acids 901 to 922 (22 residues), see Phobius details amino acids 928 to 952 (25 residues), see Phobius details amino acids 973 to 993 (21 residues), see Phobius details amino acids 1005 to 1031 (27 residues), see Phobius details PF00873: ACR_tran" amino acids 2 to 1031 (1030 residues), 1105.7 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 3 to 1040 (1038 residues), 1203.3 bits, see alignment E=0 PF03176: MMPL" amino acids 342 to 520 (179 residues), 42.9 bits, see alignment E=3.2e-15

Best Hits

KEGG orthology group: K03296, hydrophobic/amphiphilic exporter-1 (mainly G- bacteria), HAE1 family (inferred from 67% identity to chu:CHU_0941)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G347 at UniProt or InterPro

Protein Sequence (1052 amino acids)

>Echvi_3740 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family (Echinicola vietnamensis KMM 6221, DSM 17526)
MISEVFIKRPVTAMVISIVILLVGAISIVNLPVTQYPDITPPVVSVSANYTGADAKTVEQ
TVATPIETQVNGTPGMAYISSTNTSTGQMNMNVTFDVGTDIDIATLDVQNRVSIAEPRLP
EAVKRLGVTVRKRNPSIMMVISLYSPKGTHDTKFLSNYTNIFVKDALLRVPGVGDINAIG
QDFSMRVWLKPDKLAQYNISTSEVTAAIQEQNLQVAAGTVGGMPQLASQTFEYPITVNGK
LERKEEFEDIIVRTDPTSGSLVYLKDVARIEFGEFDYGRFSTVNGEPAAILLVYQAPGSN
AIDTAEGIYNALDEMKATFPADMDYVVPFESVSVVQVSIDEVLHTLVEALILVIIVVFLF
LQSWRATLIPILAIPVSIVGTFIFFIPLGFTINTLTMFGFVLAIGIVVDDAIVVVEAAQH
YIDSKRVSAKEATLLAMKDITAPVIAIALILAAVFIPVGFIPGIVGRMYQQFAITIAISV
LISAFVALTLTPALCSLLLKPMEVKKDSKGINKFFYKFNTWFERVTSSYGNGVKKSIKAT
PLVLIILVCIYAGTVGLFQVKPTGFLPTEDEGRLFISLELPESSSTSRTRAIMDEMVEMI
TTTDGIRNVTGIGGLNAINFSFKSNSGTFFVQMDPWDERQDPSKQLFGLIGQLNQKFAAI
KEANIIVVPPPAIPGLGQTGGFSFMLEQRSGGDIKEFEQVVGQFLGAANQRPEIAMAYSF
FTAKTPGYHVTVDREKAKKLGVAISDVFSTMSTYMGSAYVNDFTRYGRNFRVVAQADTAY
RMDIKDLDQYYVMNREGKSVPLGAVVDYEIVENAPVINHYNLFRSTEINGNAAEGYSSGQ
ALAALEEVAAEVLPAGYGYDFSGLSREELASGNTTILIFALAIILVSLLLAALYESWSVP
FSVLLALPLGAFGAILALTFLPKLDNNVYAQIGLVTLIGLAAKNAILIVEFAKERVDAGM
PLLAATIEAVKLRLRPIVMTSLAFILGVVPLALSNGAGAVARQTIGWTVIGGMLAATFLA
IFVVPVLYVVITKIAYGRKKLRELEEQYQPET