Protein Info for Echvi_3562 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: Aldo/keto reductases, related to diketogulonate reductase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 48% identical to A1A1B_DANRE: Aldo-keto reductase family 1 member A1-B (akr1a1b) from Danio rerio
KEGG orthology group: K00002, alcohol dehydrogenase (NADP+) [EC: 1.1.1.2] (inferred from 53% identity to abo:ABO_2414)MetaCyc: 46% identical to aldehyde reductase (Sus scrofa)
Indole-3-acetaldehyde reductase (NADPH). [EC: 1.1.1.191, 1.1.1.2]
Predicted SEED Role
No annotation
MetaCyc Pathways
- glycerol degradation to butanol (12/16 steps found)
- pyruvate fermentation to butanol I (6/8 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (3/4 steps found)
- erythritol biosynthesis I (1/2 steps found)
- erythritol biosynthesis II (1/2 steps found)
- D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
- detoxification of reactive carbonyls in chloroplasts (2/10 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (7/17 steps found)
- traumatin and (Z)-3-hexen-1-yl acetate biosynthesis (3/12 steps found)
- superpathway of lipoxygenase (4/22 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.1.1.191 or 1.1.1.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0G394 at UniProt or InterPro
Protein Sequence (319 amino acids)
>Echvi_3562 Aldo/keto reductases, related to diketogulonate reductase (Echinicola vietnamensis KMM 6221, DSM 17526) MKSLTFSNGDTMPIIGLGTWQSKPGEVYNAVLKAIEIGYRHFDCAYIYKNEKEIGDAFAK AFADGTIKREDIWVTSKLWNDSHKPEHVLPALESTLKDLQLDYLDLYLVHWPLALKHGVD FPEENGDFEHLDNIPLSTTWAAMEGLLETGKVKHIGVSNFKIEKLKEILASAKSKPEVNQ VEMHPFLPQQGLVDYCKKEGIHLTAYAPLGAAYRTQGQDGVDLPILLENDQVKNIANKLN ATTAQVVLAWNIQRDIAVIPKSVTPSRIEENFKSNLLTLSQEEMDQLNQLEGPYRFTDGK LWTTHNSPYELSDFWEEYS