Protein Info for Echvi_3452 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: ATP-dependent helicase HrpB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 869 TIGR01970: ATP-dependent helicase HrpB" amino acids 53 to 869 (817 residues), 976.5 bits, see alignment E=6.2e-298 PF04851: ResIII" amino acids 58 to 209 (152 residues), 32.1 bits, see alignment E=2.7e-11 PF00270: DEAD" amino acids 64 to 214 (151 residues), 56.9 bits, see alignment E=5.7e-19 PF00271: Helicase_C" amino acids 257 to 376 (120 residues), 46.1 bits, see alignment E=1.4e-15 PF24473: CON_HrpB" amino acids 627 to 661 (35 residues), 48.1 bits, see alignment (E = 2e-16) PF08482: HrpB_C" amino acids 724 to 857 (134 residues), 172.1 bits, see alignment E=1.8e-54

Best Hits

KEGG orthology group: K03579, ATP-dependent helicase HrpB [EC: 3.6.4.13] (inferred from 53% identity to shg:Sph21_1998)

Predicted SEED Role

"ATP-dependent helicase HrpB"

Isozymes

Compare fitness of predicted isozymes for: 3.6.4.13

Use Curated BLAST to search for 3.6.4.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G2Y5 at UniProt or InterPro

Protein Sequence (869 amino acids)

>Echvi_3452 ATP-dependent helicase HrpB (Echinicola vietnamensis KMM 6221, DSM 17526)
MVCQNFAKADGNAQLRSKDHHQRIFQVELTVIATYLWGLNDISVTFDPSNINLPVLEIIP
QVKQQLERNHTLILHAPPGAGKSTVVPLALMEETWLKGKKILMLEPRRLAAKSIATRMAS
LLKQPVGHQVGYRIRFESKATEDTQIEVLTEGIMTRMIHHDNALEEVGLVIFDEFHERNI
HADVAMALCREVQQILRPDLKIMVMSATLDMPQLSDLLQAPIVESHGRQYPVEVIHTQDA
NPWALPAQMAQTIKQASQERAGDILAFLPGQGEIRKTLELLQPMLPEVKVLPLYGQLSPQ
KQQQAILPHPEGKRKVVLATSIAETSLTIEGIGIVVDSGFSRTSRFDPKSGLSKLETVKI
TKDAAAQRAGRAGRLGPGTCYRLWTKATDDRLLPFRIPEMMEADLASLCLDLVQWGIKDI
PHMTWLTPPPAGALSQAQELLEHLGAITEDQKLTPHGEALRNLPCHPRIAHMLIKAEEDG
NLALATDIAAILEEKDPLPAQTGVDINLRVEKLRRHRGINKQGKGFDRLEKVAGNYRRLF
GAAEENGPFDPYESGLILTYAYPERIAHARPGNNAQFKMTNGKIASMHHKDDLAHEAWLS
IAHVDARDGMGKIFMAAPLNPKDLASLVKEIEMVDWDLKNGTLVAEKQWKVGHIVLQSKP
LTSISNNLKTKAIIKAIQQDGDRLLDFNENVQQWQNRIMSLRKWKAPGEWPDISTAALLA
DPSWLGPYLDSIASADGLKKLNLLEILQYSLDYDQQHLLEKLAPTRLEVPSGSNIKLQYS
ADGEPPVLSVRLQELFGLLDTPTINDGKQGVLIHLLSPGFKPVQVTKDLRSFWENTYFEV
KKELKRRYPKHYWPEDPFKAEAVRGVKRK