Protein Info for Echvi_3285 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: homoserine O-acetyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 74% identical to METXA_CYCMS: Homoserine O-acetyltransferase (metXA) from Cyclobacterium marinum (strain ATCC 25205 / DSM 745)

KEGG orthology group: K00641, homoserine O-acetyltransferase [EC: 2.3.1.31] (inferred from 53% identity to sli:Slin_0218)

Predicted SEED Role

"Homoserine O-acetyltransferase (EC 2.3.1.31)" in subsystem Methionine Biosynthesis (EC 2.3.1.31)

MetaCyc Pathways

superpathway of L-methionine biosynthesis (by sulfhydrylation) (10/12 steps found)
L-methionine biosynthesis III (4/4 steps found)
superpathway of L-cysteine biosynthesis (fungi) (5/6 steps found)
L-homocysteine biosynthesis (2/2 steps found)
superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae) (7/10 steps found)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.31

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G027 at UniProt or InterPro

Protein Sequence (351 amino acids)

>Echvi_3285 homoserine O-acetyltransferase (Echinicola vietnamensis KMM 6221, DSM 17526)
MNLTSPYLITDMTQETFHCEEELNLESGESLPGFEISYTTQGHLTPKKDNVIWILHALTG
DANVHEWWSGLVGEDKFFDPTKYFIVCANLLGSCYGSTQPLSDNPKTGKPYYYDFPNLST
RDMAKAFDRLRQHLGIQQIDTIIGGSLGGQVALEWSYNLQEQVKKTIIVASNAKTSPWTI
GFNEAQRMAIESDSTWGQNSPDAGKKGLEAARAIGMLSYRHQDIFHASQAETEEKTDHFR
VSSYLRYQGQKLSNRFNALSYWVLTKAMDSHDLGRGRGGTAKALSAIKAKVLSIGINTDL
LFTKEESQFISKNVPNGTYREISSIYGHDAFLVENEQLNYILTSFYLENND