Protein Info for Echvi_3219 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Zn-dependent alcohol dehydrogenases

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF08240: ADH_N
  • amino acids 31 to 135 (105 residues), 108.4 bits, E=2.6e-35
• PF00107: ADH_zinc_N
  • amino acids 180 to 304 (125 residues), 111.4 bits, E=4.6e-36
• PF13602: ADH_zinc_N_2
  • amino acids 212 to 339 (128 residues), 41.9 bits, E=3e-14

Best Hits

Swiss-Prot: 64% identical to ADHA_RHIME: Alcohol dehydrogenase (adhA) from Rhizobium meliloti (strain 1021)

KEGG orthology group: K13953, alcohol dehydrogenase, propanol-preferring [EC: 1.1.1.1] (inferred from 68% identity to aaa:Acav_2019)

MetaCyc: 66% identical to furfuryl alcohol dehydrogenase (Cupriavidus pinatubonensis JMP134)
Alcohol dehydrogenase. [EC: 1.1.1.1]; 1.1.1.- [EC: 1.1.1.1]

Predicted SEED Role

"Alcohol dehydrogenase (EC 1.1.1.1)" in subsystem Fermentations: Mixed acid or Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 1.1.1.1)

MetaCyc Pathways

• 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
• ethanol degradation II (3/3 steps found)
• pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
• acetaldehyde biosynthesis I (1/1 steps found)
• phytol degradation (3/4 steps found)
• L-isoleucine degradation II (2/3 steps found)
• L-leucine degradation III (2/3 steps found)
• L-valine degradation II (2/3 steps found)
• ethanol degradation I (1/2 steps found)
• pyruvate fermentation to ethanol II (1/2 steps found)
• superpathway of anaerobic sucrose degradation (13/19 steps found)
• L-phenylalanine degradation III (2/4 steps found)
• L-tyrosine degradation III (2/4 steps found)
• salidroside biosynthesis (2/4 steps found)
• heterolactic fermentation (12/18 steps found)
• L-methionine degradation III (1/3 steps found)
• pyruvate fermentation to ethanol I (1/3 steps found)
• pyruvate fermentation to ethanol III (1/3 steps found)
• mixed acid fermentation (10/16 steps found)
• phenylethanol biosynthesis (2/5 steps found)
• cytidine-5'-diphosphate-glycerol biosynthesis (1/4 steps found)
• serotonin degradation (3/7 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
• (S)-propane-1,2-diol degradation (1/5 steps found)
• acetylene degradation (anaerobic) (1/5 steps found)
• ethanolamine utilization (1/5 steps found)
• butanol and isobutanol biosynthesis (engineered) (3/8 steps found)
• superpathway of N-acetylneuraminate degradation (13/22 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (10/19 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (2/9 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (7/17 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• L-tryptophan degradation V (side chain pathway) (1/13 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• 3-Chloroacrylic acid degradation
• Drug metabolism - cytochrome P450
• Fatty acid metabolism
• Glycine, serine and threonine metabolism
• Glycolysis / Gluconeogenesis
• Metabolism of xenobiotics by cytochrome P450
• Retinol metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.1

Use Curated BLAST to search for 1.1.1.1

Sequence Analysis Tools

See L0G2A9 at UniProt or InterPro

Protein Sequence (343 amino acids)

>Echvi_3219 Zn-dependent alcohol dehydrogenases (Echinicola vietnamensis KMM 6221, DSM 17526)
MLPKTMKAAVVTEFGQPLKIEEIPVKAPNENQILVQVMASGVCHTDLHAADGDWPVKPRL
PLIPGHEGIGYVAAVGSNVKNTKEGDIVGVPWLYSACGHCEHCITGWETLCESQVNGGYS
VDGGYAEYVLADPNYVGRFSGAIDFVQMAPILCAGVTVYKGLKETEVRPGQWVAISGIGG
LGHVAVQYAKAMGLHVLAVDVSDDKLNLAKKLGADRVVNGKNPDEVMNARKETGGVHGVL
VTAVSPVAFRQALDLLRRKGTLVMNGLPPGSFDLPIFETVLNRYTVRGSIVGTRKDLQEA
IDFAMEGKVTTTVKSAPLEDINLIFDQMKKGQIEGRMVLDIGH