Protein Info for Echvi_3202 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: copper-(or silver)-translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 684 transmembrane" amino acids 52 to 72 (21 residues), see Phobius details amino acids 84 to 102 (19 residues), see Phobius details amino acids 115 to 137 (23 residues), see Phobius details amino acids 143 to 160 (18 residues), see Phobius details amino acids 294 to 316 (23 residues), see Phobius details amino acids 328 to 355 (28 residues), see Phobius details amino acids 632 to 652 (21 residues), see Phobius details amino acids 658 to 678 (21 residues), see Phobius details TIGR01511: copper-translocating P-type ATPase" amino acids 98 to 679 (582 residues), 596.2 bits, see alignment E=1.4e-182 TIGR01525: heavy metal translocating P-type ATPase" amino acids 116 to 677 (562 residues), 590.3 bits, see alignment E=9.4e-181 TIGR01494: HAD ATPase, P-type, family IC" amino acids 150 to 664 (515 residues), 293.3 bits, see alignment E=5.4e-91 PF00122: E1-E2_ATPase" amino acids 178 to 355 (178 residues), 177.9 bits, see alignment E=2.3e-56 PF00702: Hydrolase" amino acids 373 to 586 (214 residues), 113.6 bits, see alignment E=2.4e-36

Best Hits

Swiss-Prot: 57% identical to COPB_ARCFU: Copper-exporting P-type ATPase B (copB) from Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126)

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 68% identity to mtt:Ftrac_2065)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (684 amino acids)

>Echvi_3202 copper-(or silver)-translocating P-type ATPase (Echinicola vietnamensis KMM 6221, DSM 17526)
MEKHNHEHHKHHTHAGHQKSQSSDHQTINKSDHQHGHHDHHAMMIEDFKKRFWISLVLTV
PILALSHMIQQLLGFELTFFGDQYVLFGLSTIVFFYGGWPFLKGLWSRLKDKNPGMMTLI
AVAITVAYVYSSAVVFGLEGMDFFWELATLIVIMLLGHWIEMKSVMGASRALELLVQMMP
SEAHLVQGDQIKDIKVDQLKKEDIILIKANEKKPADGTVVDGESHLDESMLTGESKPVKK
SKGDPVIGGSVNGSQSIKVKVSKTGKESYLNKVITLVEEAQKAKSKTQNLANVAARWLTF
IAIGAGTITLFTWISLGKPLDFALERMVTVMVISCPHALGLAIPLVVAISTAVSAGKGLL
IRNRTAFENARKITAMVFDKTGTLTEGKFGVSRYESLSDDMNKNELLSFAASLEQQSEHP
IAQGIVKAAKEAGLALKKVENFESLTAKGIQGKIEGQNWKVVSPGYLKENDINIPDQAGS
DEAETIVYVLQENLIIGFIALSDQIREESPKAIETLREKGMKLYMATGDNEKTAKAVSEK
LGLDGYYSEVLPHQKVEIIKKLQKEGHFVAMTGDGVNDAPALAQANVGIAVGSGTDVAAE
TADIILVNSNPKDIANLVLFGRATYNKMIQNLAWATGYNAIALPLATGFIPGLVISPAIG
AVFMSLSTVIVAINAQLLKRKIKN