Protein Info for Echvi_2997 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: Exopolyphosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02541: Ppx-GppA
  • amino acids 27 to 282 (256 residues), 127 bits, E=5.2e-41

Best Hits

KEGG orthology group: K01524, exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC: 3.6.1.11 3.6.1.40] (inferred from 59% identity to mtt:Ftrac_3205)

Predicted SEED Role

"Exopolyphosphatase (EC 3.6.1.11)" in subsystem Phosphate metabolism (EC 3.6.1.11)

MetaCyc Pathways

• ppGpp metabolism (6/6 steps found)
• polyphosphate metabolism (2/2 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.11, 3.6.1.40

Use Curated BLAST to search for 3.6.1.11 or 3.6.1.40

Sequence Analysis Tools

See L0G314 at UniProt or InterPro

Protein Sequence (293 amino acids)

>Echvi_2997 Exopolyphosphatase (Echinicola vietnamensis KMM 6221, DSM 17526)
MKLAAVDIGSNAIRLQITHVTHHQEQINFKKLEYVRFPLRLGKDVFHSKKISEESKEKFI
KLMKAYKLLIDLYEVDDYMVCATSAMRESENGRAIAQEVKQDIGLKIQIIDGNREADLIN
IALWNYIDHKPYLHIDVGGGSTELNIYQNRQKIASKSFKIGSVRALDHKESPKVWKAMKT
FIQENIDKRHAITCIGTGGNINKVFELSKPRKNKRYLDFAKIQEMQAYLASFTFDERVNV
LNLNPDRADVIIPATSIYLTAMEAAHSKRMIVPDVGLKDGVMNVLYERNKNKA