Protein Info for Echvi_2860 in Echinicola vietnamensis KMM 6221, DSM 17526
Annotation: sugar-phosphate isomerases, RpiB/LacA/LacB family
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 42% identical to LACB_STAES: Galactose-6-phosphate isomerase subunit LacB (lacB) from Staphylococcus epidermidis (strain ATCC 12228)
KEGG orthology group: K01808, ribose 5-phosphate isomerase B [EC: 5.3.1.6] (inferred from 65% identity to shg:Sph21_4275)MetaCyc: 39% identical to galactose-6-phosphate isomerase lacB subunit (Staphylococcus aureus)
Galactose-6-phosphate isomerase. [EC: 5.3.1.26]
Predicted SEED Role
"Ribose 5-phosphate isomerase B (EC 5.3.1.6)" in subsystem Calvin-Benson cycle or D-ribose utilization or LMPTP YwlE cluster or Pentose phosphate pathway (EC 5.3.1.6)
MetaCyc Pathways
- superpathway of glucose and xylose degradation (16/17 steps found)
- formaldehyde assimilation II (assimilatory RuMP Cycle) (9/9 steps found)
- pentose phosphate pathway (8/8 steps found)
- Rubisco shunt (9/10 steps found)
- Calvin-Benson-Bassham cycle (11/13 steps found)
- pentose phosphate pathway (non-oxidative branch) I (5/5 steps found)
- formaldehyde assimilation III (dihydroxyacetone cycle) (10/12 steps found)
- pentose phosphate pathway (non-oxidative branch) II (5/6 steps found)
- 1-butanol autotrophic biosynthesis (engineered) (20/27 steps found)
- Bifidobacterium shunt (11/15 steps found)
- ethene biosynthesis V (engineered) (18/25 steps found)
- lactose degradation I (3/5 steps found)
- oxygenic photosynthesis (11/17 steps found)
- photosynthetic 3-hydroxybutanoate biosynthesis (engineered) (17/26 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of plant hormones
- Carbon fixation in photosynthetic organisms
- Galactose metabolism
- Pentose phosphate pathway
Isozymes
Compare fitness of predicted isozymes for: 5.3.1.6
Use Curated BLAST to search for 5.3.1.26 or 5.3.1.6
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See L0FYW8 at UniProt or InterPro
Protein Sequence (151 amino acids)
>Echvi_2860 sugar-phosphate isomerases, RpiB/LacA/LacB family (Echinicola vietnamensis KMM 6221, DSM 17526) MKIGIAADHGGFDQKQELYEYLKSNGHDVTDFGAFEFDESDDYPDKVKPLAIAVSKGEIQ KGIAICGSGVGVTVAANKVPGVRAALITEPYSAHQGVEHDNMNLMCLGGRVMGGVVLKEL VEIFITAEYVEKERFQRRLKKVQDLENEFLK