Protein Info for Echvi_2785 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: putative efflux protein, MATE family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 463 transmembrane" amino acids 30 to 55 (26 residues), see Phobius details amino acids 74 to 95 (22 residues), see Phobius details amino acids 107 to 129 (23 residues), see Phobius details amino acids 149 to 170 (22 residues), see Phobius details amino acids 182 to 205 (24 residues), see Phobius details amino acids 212 to 234 (23 residues), see Phobius details amino acids 255 to 277 (23 residues), see Phobius details amino acids 287 to 314 (28 residues), see Phobius details amino acids 337 to 361 (25 residues), see Phobius details amino acids 370 to 391 (22 residues), see Phobius details amino acids 405 to 426 (22 residues), see Phobius details amino acids 432 to 453 (22 residues), see Phobius details PF01554: MatE" amino acids 36 to 196 (161 residues), 109 bits, see alignment E=9.7e-36 amino acids 265 to 422 (158 residues), 108.5 bits, see alignment E=1.5e-35 TIGR00797: MATE efflux family protein" amino acids 36 to 434 (399 residues), 284 bits, see alignment E=9e-89

Best Hits

KEGG orthology group: None (inferred from 54% identity to fbc:FB2170_10576)

Predicted SEED Role

"Multi antimicrobial extrusion protein (Na(+)/drug antiporter), MATE family of MDR efflux pumps" in subsystem Multidrug Resistance Efflux Pumps

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0FYQ2 at UniProt or InterPro

Protein Sequence (463 amino acids)

>Echvi_2785 putative efflux protein, MATE family (Echinicola vietnamensis KMM 6221, DSM 17526)
MTLTNIIHHFKKALSGEEEDFTVGSIRKAIFYLSIPMILEMLMESLFAVVDIFFVGKLGV
QAVATVGLTESVLTIVYSVAIGLSMAATAVVARRIGEKKKKAASQAAFQAIIICAVLAMT
IGVLGLFFAKDLLTLMGGDPALVASGFGYTQVIFAGNISVMLLFLINGVFRGAGNAVIAM
RTLWLANGINIVLDPMLIFGIGFFPELGLEGAAWATTIGRSVGVLFQLSVLFRGKAIISF
NWDVLRFRWYTVKNILKIAIGGMGQFLIESASWIVLMRIVSNSGSVALAGFTIAIRLIIF
ALLPAMGFSNASATLVGQNLGAKRPDRAEQSAWKAAHYTALFLGSIGLLFFFFGEYIISW
FNDNPEVIQVGTDGLGIICLGYVFFAYGMVMSQSLNGAGDTKTPTLINIVVLWLFQLPLA
YVLSQWFDMGEIGVFIAIAVGHSVHALVSGFIFNQGKWKLKEV