Protein Info for Echvi_2781 in Echinicola vietnamensis KMM 6221, DSM 17526

Annotation: The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1042 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 330 to 349 (20 residues), see Phobius details amino acids 356 to 377 (22 residues), see Phobius details amino acids 383 to 407 (25 residues), see Phobius details amino acids 428 to 448 (21 residues), see Phobius details amino acids 460 to 487 (28 residues), see Phobius details amino acids 527 to 547 (21 residues), see Phobius details amino acids 861 to 879 (19 residues), see Phobius details amino acids 886 to 908 (23 residues), see Phobius details amino acids 914 to 939 (26 residues), see Phobius details amino acids 963 to 986 (24 residues), see Phobius details amino acids 994 to 1017 (24 residues), see Phobius details PF00873: ACR_tran" amino acids 2 to 1017 (1016 residues), 1027.3 bits, see alignment E=0 TIGR00915: RND transporter, hydrophobe/amphiphile efflux-1 (HAE1) family" amino acids 2 to 1033 (1032 residues), 1043.1 bits, see alignment E=0 PF03176: MMPL" amino acids 275 to 490 (216 residues), 43.7 bits, see alignment E=2.7e-15

Best Hits

Swiss-Prot: 41% identical to BEPG_BRUSU: Efflux pump membrane transporter BepG (bepG) from Brucella suis biovar 1 (strain 1330)

KEGG orthology group: None (inferred from 66% identity to sli:Slin_6591)

Predicted SEED Role

"RND efflux system, inner membrane transporter CmeB" in subsystem Multidrug Resistance Efflux Pumps or Multidrug efflux pump in Campylobacter jejuni (CmeABC operon)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See L0G2G9 at UniProt or InterPro

Protein Sequence (1042 amino acids)

>Echvi_2781 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family (Echinicola vietnamensis KMM 6221, DSM 17526)
MVISLFFVLLGALTFFSLPVALFPDIAPPAVSIRAKYRGANSEVVAKTVTTPLEKAINGV
PGMMYMSSVSSNRGTSKIKVYFGAETSPDEAAMEVQNRVSTVVNDLPQDVIKAGVTVEKE
VEGLLLYINVMGSDPSMDEQFIYNFSDLNVLQELRRVDGVGFAEIMSTKDYSMRIWLKPD
RMTAYQVSTDEVKAALNNQNVEAAPGQVGVSSGKGAQMIQYGLRYSGKFNEAKEYENLVI
RANKDGSILRLGDIADVEFGSLNYGRISKTDGKPAASIMIIQRPGSNARDVIQRVKKRME
ELKQGSFPPGVDYKITYDVSRFLDASIHEVLKTLIEAFILVFLVVFIFLQDFRSTLIPAL
AVPVALIGTLFFMQLFGFSINMLTLFALVLAIGIVVDNAIVVVEAVHAKMEEDHLPPMEA
TLAAMKDIGGAIVSITLVMSAVFIPVAFLDGPVGIFYRQFSITLAIAIVISGINALTLTP
ALCAIILKNHYGTEQKKTLLNTFFNGFNRAYESFSGKYRNTLGVLVGRRLVTVIMLVAFF
IGTWGVAKVLPSGFIPVEDQSMVYINVVSPSGATVERTEKVLDHIQQAAEELDEVAAVST
LAGYSLSTGLSGASYGMGMINLKNWDEREASIQETIDELYARTADISDAQVQFFLPPTVS
GFGNSSGFQMKVLDQTGSGNLQKLSLVIEDFVEALDNAPEIGEVKSDFDPNFPQYMVNVD
QDMAAKKGVTISNAMSTLQILMGGVLASDFVRFENMYDVMMQAGPQYRANPEDVLKVHVK
NDGGEMVPISSFINLEKVYGPEQLSKHNMYTSAKVKGIPAPGYSSGDAVAAIQRVAAEKL
PKGYGYDWYGMTRQEVSSGNQAIYIFIICLVFVYLLLAAQYESFVLPLPVILFLPAGVFG
SFAALYLLGLQNNIYAQVALIMLIGLLGKNAILIIEFAVLKRKEGMDIIPAAITGAVSRL
RPILMTSFAFMAGLVPLCMATGAGALGNRSIGTAALGGMFSGTVFGMFLIPGLYVLFSSR
RKKNKTKMKNKVENIAVSLSNN